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Prevention of MTX induced psychological intolerance in children with Juvenile Idiopathic arthritis.

The aim of this study is to explore the incidence of MTX related gastro-intestinal in a large cohort of JIA patients. Secondly, we want to investigate the effect of psychological behavioural therapy or switch to parenteral MTX dosing to ameliorate…

Computer-tailored health information for parents with young children combined with personal counselling in well-child care.

The computer-tailored health information in combination with personal counselling leads to: 1. Improvement of health behaviors; 2. Improvement of parental satisfaction with well-child care visits; 3. Improvement of well-child care provider…

Alcohol supplementation in Rhizomelic chondrodysplasia punctata
in the Netherlands.

Plasmalogens can be synthesized out of batyl alcohol (naturally occuring alkylglycerol) in patients with the peroxisomal disorder rhizomelic chondrodypslasia punctata (RCDP), bypassing the peroxisomal steps in the pathway.

Anti-CD20 therapy for the treatment of
chronic graft versus host disease.

B cells contribute to the development of cGVHD.

Ruptured Aortic Aneurysm Study with the Aanconda bifurcated endograft. A monocenter, prospective, feasibility pilot study. (RASA)

The prupose if this study is; to accesss the feasibility of treatment of rAAA with a bifurcated endograft with the magnetic wire system to speed up the contralateral gate access.

Hyperechogenicity of the thalamus and basal ganglia in very preterm infants.

The principal aim of this research project is to establish the origin of increased echogenicity in the thalami and basal ganglia (ED/TDG), an ultrasonographic finding fequently encountered in very preterm infants. It is not known whether ED/TBG is a…

Short-term Cognitive Behavioral Therapy and Short-term Psychoanalytical Supportive Psychotherapy as treatment for depression: a randomized clinical trail.

N/A

A single center open-label uncontrolled study to investigate tumour response and vascularization changes in neoadjuvant therapy with BAY 43-9006 single agent therapy in patients with operable renal cell cancer.

In view of good pre-clinical and clinical results, it is thought that patients with renal cell cancer will benefit from BAY 43-9006 in a neoadjuvant setting.We anticipate a benefit with the treatment of BAY 43-9006 when there is a tumour reduction…

Macula off rhegmatogenous retinal detachment and its functional recovery.

Optimum timing of surgery for macula off rhegmatogenous retinal detachment can be determined in more detail by taking both duration and height of macular detachment into account.

GROningen INternational Study on Sentinel nodes in Vulvar cancer. An observational study.

Is is safe to replace inguinofemoral lymphadenectomy by adjuvant radiotherapy in early stage vulvar cancer patients with a metastatic SN?

A randomized, prospective, multicenter study of the effective treatments of panic disorder: cognitive behavioral versus antidepressants versus a combination therapy.

On short-term, the Combined treatment is expected to be superior to either mono-treatment. On long-term it is expected that CBT will prove to be more durable and that patients in the SSRI will require more mental health care during the one-year…

Pre- and neonatal screening of hemoglobinopathies: a prospective study.

The carrier frequence of hemoglobinopathies is > 0,05 and screening for primary prevention is cost-effective.