38 resultaten
Primairy Objectives: - To evaluate the antitumoral efficacy of celecoxib in combination with docetaxel/carboplatin in terms of: a) response (cCR, cPR, NC, PD) b) progression-free survival Secundairy Objectives: -To evaluate the safety and…
A single MenC polysaccharide-protein conjugate vaccination was introduced into the National Vaccination Program (RVP) at the age of 14 months in 2002. Furthermore in 2002, in a large national campaign all children and adolescents between the age of…
The exerted pressure on the skin by non-invasive pelvic circumferential compression devices (PCCDs) carries a risk of pressure sores and skin necrosis in case of prolonged use. A persons Body Mass Index (BMI) is of influence on this risk.
Prevenar® is thought to induce immediate protection through stimulation of antibody production by polysaccharide specific plasma B cells, sustained protection is conferred by a memory B cell pool which induces an accelerated increase in antibody…
Long-chain triglyceride (LCT) emulsions with very small droplet sizes (fine emulsion) will lead to enhanced postprandial satiety and reduced energy intake in a subsequent meal, as compared to LCT emulsions with relatively large droplet sizes (coarse…
Outpatient LMHW treatment in patients with objectively proven non-massive pulmonary embolism is efficacious and safe.
It is safe and feasible to administer autologous bone marrow derived MSCs for treatment of Crohn's Disease (CD).
We postulate the following hypotheses: 1. In patients presenting with myocardial infarction high serum glucose values at admission has a harmful influence on infarct size and left ventricular function (LVF) 2. Systematic, frequent and…
In lungcancer bone metastases appear frequently en they are an important cause of pain. The expectation is that Bondronat® gives a fast pain reduction. In this phase II study will be examined whether this fast pain reduction indeed occurs and if…
In patients with non-insulin dependent type 2 diabetes, intensive, short term physical activity is associated with decreased blood glucose levels and number of cardiovascular complications. In patients who are insulin dependent however, the effects…
Ho: the life birth rate in patients after SET with only morphological embryo selection is equal to patients with metabolomic profiling added to morphological selection. H1: the life birth rate in patients after SET with only morphological embryo…
To test if an intraoperative NIRF camera system can detect a NIRF optical contrast agent for SLN in patients with palpable breast cancer.
We postulate that exhaled breath sampling by an electronic nose can adequately identify newly presented patients with COPD in an at risk population ((ex-)smokers), regardless of symptoms.
Anti CD20 therapy will result in complete or partial response in patients with chronic GVHD, who do not respond to first line treatment.
We hypothesize that ER of endoscopically visible abnormalities followed by stepwise circumferential and focal RFA of the residual BE will effectively remove the HGD and EC and will completely remove all Barrett's mucosa without significant…
Muscle hypoxia, either chronic or intermittent (exercise-induced), is responsible for the altered muscle oxidative phenotype in chronic obstructive pulmonary disease and chronic heart failure through modulation of the regulatory molecules PGC-1/…
The primary aim of this study is to investigate objectively, electronically measured noncompliance to inhaled corticosteroids in a multicultural population of children with asthma. Furthermore, the association of determinants such as ethnicity, age…
There are two research questions: 1. What is the effect of a minimal CBT intervention for CFS in primary care carried out by trained social psychiatric nurses? 2. What are the characteristics of CFS patients who do not improve by a minimal…
Providing AAA patients with a decision aid concerning watchful waiting or elective surgery will decrease their decisional conflict, increase their knowledge on treatment options, increase satisfaction and increase quality of life.