168 resultaten
Magnetic resonance imaging (MRI) and magnetic resonance spectroscopy (MRS) are non-invasive imaging modalities that can image plaque composition in-vivo in human carotid arteries with high sensitivity and specificity with regards to calcification,…
Hepatic HSPG expression is altered in DM2 patients with NASH compared to controls and determines level of insulin resistance.
The aim of the meta-analysis is to further investigate the early predictive value of migration measured by RSA 1 year post-operatively for revision for aseptic loosening in TKA and to compose migration thresholds for safe and efficient clinical…
Measuring ER-density with FES-PET can be used as a predictive test to select patients sensitive for estrogen therapy.
The diagnosis of biliary atresia may be confirmed by intraoperative fluorescence cholangiography using intravenously or biliary administered indocyanine green.
The protein content of a product has an influence on satiety, e.g. the higher the protein content, the lower the subsequent intake. In addition, a sensory specific satiety effect is expected, meaning that after eating a preload with a certain taste…
Pre-operative accelerated partial breast radiotherapy will be superior compared to conventional radiotherapy for fibrosis and cosmetic outcome, and we think this new treatment will be superior to conventional post-operative whole breast radiotherapy…
To assess the current indications for HPS greenlight laser treatment and the treatment outcomes in terms of objective and subjective improvement.
We hypothesize that the neurologic prognosis of patients with post-anoxic encephaloptahy (due to a cardiac arrest) could be improved by combining SSEP measurements with continuous EEG monitoring and transcranial magnetic stimulation (TMS)…
1. To assess four different clinical decision rules (Wells rule, revised Geneva decision rule, simplified Wells rule and simplified revised Geneva decision rule) in the exclusion of pulmonary embolism; 2. To evaluate the safety of withholding…
Primary Objectives: 1. A quantification method for vasa vasorum imaging using contrast-enhanced ultrasound of the carotid arteries will be developed, using physical ultrasound parameters; 2. The vessel wall thickness (intima-media thickness) and…
We hypothesize that the ASM phenotype of asthmatic patients: 1. Changes during an experimental, rhinovirus type 16 (RV16)-induced exacerbation; 2. Is associated with enhanced airway inflammation and hyperresponsiveness during an experimental, RV16-…
We propose that kinase activity profiling may be a potential clinical diagnostic tool to predict for tumor response to targeted therapy with tyrosine kinase inhibitors (TKI's).
The pharmacotherapeutic treatment of patients with cancer is generally associated with multiple side-effects. The cause of the side-effects is usually due to the toxicity of the drugs themselves. In addition, drug interactions can intensify side-…
Gaining knowledge on human responses against the influenza virus will help us in treating influenza infections and lead to more effective vaccines. Additionally, it might also lead to identification of individuals that have a high risk of morbidity…
The nephrotoxicity caused by cisplatin is of great concern both in that it is dose-limiting and can be detrimental to the patient. Much work has been done to reduce or prevent this damage to renal cells, however to date the best approach has reduced…
To test the accuracy of dynamic MRI with T1 mapping in patients with CD and compare this with know parameters such as CDEIS, CRP and CDAI.
The present study aims to get more insight into the various aspects that govern adherence to the oral anticancer drug capecitabine in daily practice.
Is there a difference in the recurrence rate if you treat a cyst or abscess of the bartholin gland with a marsupialization or placement of a word catheter.
We hypothesize that subjects suffering from hypothalamic dysfunction may have a hyposerotonergic neurotransmission. Therefore we will investigate if there are differences in specific hypothalamic-to-nonspecific [123I]FP-CIT binding ratios using…