225 resultaten
In this explorative study we will examine the impact of daily ischemic preconditioning on brachial artery endothelial function (measured as FMD%, before and after IRI) during 7 days in the non-shunt arm and lower limb in patients with end-stage…
Different studies have shown that a hunter-gatherer type diet is effective in improving glucose regulation and lipid profile. I want to investigate if the hypothese that this type of diet also reduces the number of physical and psychological…
RRT activation rate within a hospital or wards within a hospital are likely to be associated with specific factors regarding possible delay in escalation of care for deteriorating patients. This research is focussed on elucidating factors which may…
- Hypothesis#1 efficacy We hypothesize that a quick onset, and a predictable dose-response, good adjustability of analgesia can be achieved with inhaled ketamine. Hypothesis#2 safety Inhalation of nebulized ketamine might lead to a fast onset of…
Perfusion Angiography, in relation with known parameters, describes the ultimate prognostic model in revascularized Critical Limb Ischemia patients.
Our hypothesis is that high-dose, pulsatile sorafenib may exhibit improved efficacy with an acceptable toxicity profile compared to standard continuous dosing. AUC escalation cohorts are used instead of the conventional dose escalation cohorts,…
MIA is a good alternative for the CA, with comparable diagnostic performance. It will lead to an increase in clinical autopsy rates, which have significantly decreased over the last decades in both academic and non-academic medical centers.
The RAINBOW study: Rheumatoid Arthritis ImplemeNtation of Biological dose Optimization in real World
We hypothesize that a multifaceted implementation strategy can stimulate the use of tight control and bDMARD dose optimization in clinical practice, measured by decreased bDMARD use and non-inferiority on disease activity at 18 months.
Patients subject to MET review have a high in-hospital mortality (20%). Thus, understanding the outcome of patients within the first 24hr of MET review is important in developing quality improvement and interventional studies to reduce this…
The null-hypothesis predicts that Inlife is not feasible. The alternative hypothesis predicts that the Inlife intervention is evaluated as being feasible. We expect the alternative hypothesis to be true. Inlife will be feasible and minor revisions…
The EuraHS-QoL questionnaire is a valid instrument to measure quality-of-life before and after ventral hernia repair.
We expect that mp-MRI, molecular urine test and Prostate Cancer Risk Calculator may be of additional value in differentiating between significant and insignificant cancers in men with an elevated PSA in the primairy diagnosis. If so, it will result…
The primary objective of this study is to explore the correlation between invasive and non-invasive haemodynamic variables and monitor the effect of treatment during admission for acute decompensated heart failure. In particular to investigate…
Health outcomes for people at risk of or suffering from non-communicable lung diseases in low-resource settings will be improved by developing capacity for implementation of evidence-based interventions for prevention, diagnosis and treatment in…
For the prevention of diabetic foot ulceration, evidence exists to support the use of home-monitoring of foot skin temperature by means of a hand-held infrared skin thermometer. However, the construct validity of skin temperature measurements is…
Muscular counterpulsation (MCP) is a new treatment option which seems to improve hemodynamics but might also have positive effects on muscular and vascular function. Additionally, it is non-invasive and does not seem to have relevant side effects.…
By offering a screeningstool for OSAS in the first line (general practitioners), it is expected that diagnosing OSAS becomes easier, faster, cheaper, more efficient, patientfriendly, and is also accessible to a wider audience.
First objective: To study the influence of mucositis on the absorption of sublingually delivered fentanyl (Abstral ®) in head and neck cancer patients treated with chemoradiotherapy. Secondary objectives: to study the influence of xerostomia on the…
The doctor-patient-relation is a powerful and important tool in the complex care for patients with (chronical) MUS.