28 resultaten
We hypothesize that it is possible to culture circulating tumor cells obtained by leukapheresis into organoids.
Screening of esophageal cancer can be improved by the optical detection of field cancerization
To investigate the impact of an open label non-mandatory switching strategy from Enbrel to Benepali on drug survival, effectiveness and safety in a controlled cohort study of RA, PsA and SpA patients in daily practice.
To determine the influence of prednisone on docetaxel pharmacokinetics compared to docetaxel alone
The beneficial effect of cold acclimation on insulin sensitivity is reproducible and the effect wil sustain for a longer period of time. Besides insulin sensitivity, cold acclimation also has beneficial effects on cardiovascular risk factors in type…
The main objective of this study is to determine the rate people convey information through their hand. The secondary objective is to assess the mental workload of the subjects through a questionnaire. Moreover, as we already have pilot data from…
Family Group Conferences will improve disability-management self-efficacy and participation in patients with amputation, acquired brain injury and spinal cord injury and their relatives
The Victoria modules are thought to have a positive effect on acknowlegdement for adversities and risk awareness. This can be used to take acceptable risks in rehabilitation process. This will then lead to more societal participation and less…
The purpose of this study is: 1. To investigate the effectiveness of teacher training in Classroom Pivotal Response Teaching (CPRT) on teacher-created opportunities 2. To investigate the effectiveness of CPRT on children's communication…
intravenous immunoglobulins will induce a fast and effective response in patients with newly diagnosed idiopathic inflammatory myopathies. Also, the treatment will be generally safe. Furthermore, this pilot study will show feasibility with respect…
We hypothesize that age-related changes in hepatic and intestinal drug metabolism affect the pharmacokinetics of midazolam.
In TMD patients with concomitant headache, t is hypothesized that treatment of the TMD complaints will have a positive effect on the headache as well. The effect size is expected to depend on the type of headache, with the strongest effect for…
We hypothesize a priori that the Dutch NAT: PD-HF will be a feasible and acceptable tool to identify palliative care needs in patients with CHF and will initiate appropriate management.
The main outcome is the identification of clinical, biochemical, and genetic factors associated with resilience to cognitive decline in extreme elderly subjects. At baseline we will test the association between cognitive resilience and amyloid…
Urinary and (peripheral and central) intravenous catheters are widely used in hospitalized patients, although some serious complications can occur with the use of these catheters. Up to 56% of the catheters do not have an appropriate indication. The…
We expect that the Dutch language versions of the AOFAS Ankle-Hindfoot and the AOFAS Midfoot score will have adequate measurement properties (e.g. reliability and validity).
Exploration of the effects of AAT in adults with an Autism Spectrum Disorder (because this study has an explorative character, there is no hypothesis formulated)