4945 resultaten
• To determine if buprenorphine action at the MOR receptor can inhibit the respiratory depression response to IV fentanyl injection in healthy subjects and patients with chronic opioid use; • To determine if therapeutic concentrations achieved with…
It is hypothesized that chicken eggshell membrane is effective in the regeneration of cartilage and/or immunomodulation (oral tolerance), and as such positively affects pain and stiffness in joints commonly affected in arthritis
Early antipyretic therapy reduces the risk of death or dependency in patients with acute stroke, even if they are normothermic
Metformin combined with doxycycline will result in a better improvement in HS severity and the pre-diabetic condition of the patients compared to doxycycline monotherapy.
Ezetimibe monotherapie lowers LDL-C levels, plant sterol levels and inflammatory markers in young children with familial hypercholesterolemia.
In this study we will validate nerve excitability threshold tracking, a measurement technique for neuronal excitability. The placebo-controlled mexiletine and lacosamide administration should inform us about the sensitivity of threshold tracking to…
The study will assess drug-induced change in performance in divergent thinking and goal-directed behaviour when comparing psilocybin to placebo, before and after an induction of stress. Additional study parameters include frontal-subcortical…
PRP injections are efficacious for symptom reduction and functional improvement compared to placebo injections in the treatment of ankle (talocrural) OA.
1. DCS enhances the speed and size of effect of exposure therapy in panic disorder and OCD; 2. This DCS enhancement is independent of the nature of the anxiety provoking situations (OCD-related versus panic-related); 3. There is no difference in…
Early IVIg treatment in addition to prednisone results in a meaningful clinical response in treatment naive myositis patients in the short term and increased HR-QoL in the long term
Is hydrocortisone safe and effective in reducing the incidence of the combined outcome death or BPD at 36 weeks PMA in chronically ventilated preterm infants, as compared to placebo.
Ascorbic acid has shown to have a favorable influence on myelination in in vitro studies and in a mouse model for CMT1A. We will study the efficacy and safety of ascorbic acid treatment in young patients with CMT1A.
The null hypothesis states there is no difference in effectiveness of the ESPB compared to placebo on early postoperative pain intensity measured with NRS in patients that underwent lumbar spine fusion surgery.
It is hypothesized that exercise therapy and CBT are both effective in reducing fatigue and improving activities and QoL in patients with Postpoliomyelitis Syndrome (PPS) compared to the usual care.
A single subanesthetic dose of intranasal ketamine is able to diminisch acute suicidal ideation and behaviour, regardless of the underlying diagnosis.
we hypothesize that translocation of Gram- negative intestinal bacteria is associated with changes in (small) intestinal microbiota composition and can be influenced by fecal microbiota transplantation.
In the present study we will investigate the efficacy of Lybridos in one group of subjects with FSD in the laboratory. We will measure subjective, physiological and neuropsychological measures of sexual functioning in the Emotional Brain laboratory…
Based on Faber ea. 2006, we expect that the effectiveness of ‘In Balans’ can be replicated and extended in a group of community-dwelling pre-frail and non-frail older adults with an increased risk of falls, with a significant reduction of the number…
In this study we will investigate whether changes in gutmicrobiota composition induced by allogenic donor fecal transplantation (from longterm type 1 diabetes mellitus patients with preserved beta cell function) compared to placebo, , has…