4945 resultaten
To evaluate the effect of an enhanced perioperative care program added on to usual care. It is hypothesized that the enhanced perioperative care and health protection (EPOCH) program added on to usual care reduces postoperative surgical site…
Consumption of foods containing L-arabinose will improve glycaemic and insulinemic response.
Type 2 diabetes is a major threat to human health. Disruption of the circadian timing system is associated with metabolic changes. Disturbance of the daily light and dark rhythm could contribute to this phenomenon and effects metabolic pathways. We…
The study will investigate the effect of a synbiotic test product compared to a control product on the composition and metabolic activity of the gut microbiota of C-section delivered infants.
We hypothesize that alfentanil will reduce maximum pain score by at least 1.3 point on a 11-point numeric rating scale.
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Acute challenges with cocaine and cannabis will induce two opposing dopaminergic states in the brain. Cocaine will stimulate dopamine release leading to hyperdopaminergia whereas cannabis will reduce central dopamine levels resulting in…
OTR4120 will improve healing of chronic ulcers.
The central hypothesis of our study is that routine postsurgical anesthesia visits reduces postoperative 30-day mortality by 30%.
Counteract the process of mental deterioration in elderly people through enhancement of their EPA-DHA status.
We hypothesize that our individual rehabilitation program will be (cost-)effective regarding the primary and secondary health- and work-related outcome measures of work in cancer survivors with an employment contract, compared to care as usual.…
The administration of probiotics to breastfeeding females exert a direct influence on the development of the infant gut microflora through the transference of selected strains.
Brain activity in people with schizophrenia differs when compared to brain activity of people who do not have this condition. There is evidence that the negative symptoms of schizophrenia are related to reduced cortical activation involving the…
We expect that oxytocin treatment alone will reduce trauma-related psychopathology at one-and-a-half month follow-up compared to participants who received placebo. fMRI substudy: we expect that a single oxytocin administration will attenuate neural…
The number of colonoscopies tremendously increased in recent years and will further rise in the near future. Patients undergoing such interventions expect a safe and in particular comfortable manner of riding out those routine procedures. One…
Effect of inhaled hypertonic saline solution to treat infants hospitalizid with viral bronchiolitis.
We hypothesize that inhalation of hypertonic saline will reduce the hospital stay.
We hypothesize that: 1. Patients with mild-moderate and severe asthma have an increased procoagulant activity as compared to healthy controls; 2. Oral corticosteroids activate coagulation in healthy controls and increase the procoagulant activity in…
We hypothesize (hypothalamic) obesity can be treated with GLP-1 analogues in patients with craniopharyngioma.
•To investigate the safety and tolerability of multiple ascending oral doses of DNL104 in healthy subjects •To characterize the pharmacokinetics (PK) of DNL104 in plasma and measure the trough concentrations of DNL104 in CSF. •To Explore the…
This study is designed to study the contribution and quantification of norketamine for its analgetic and psychomimetic effects