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Prevention of progressive renal function loss remains the main challenge in clinical nephrology. Blockade of the rennin-angiontensin-aldosterone system (RAAS), which can be potentiated by a low sodium diet, is the therapy of choice, but still many…
As there is a large amount of evidence for the relation between cannabis and psychosis and the possible increase of forebrain dopamine by THC, THC-induced psychotomimetic effects could be used as a pharmacological challenge test to study the…
Is the effect of addition of the COX-2 inhibitor celecoxib to docetaxel/carboplatin chemotherapy inducing a tumour response or/and is slowing the progression.
In comparison with placebo SLIT will lead to a clinical relevant symptom reduction in 6 to 18 years old children with a rhinoconjunctivitis due to grass pollen allergy.
Targets of blood pressure, glucose and cholesterol are better feasable with rosiglitazone and structured treatment advice.
Oxytocin has effect on neural areas involved in human social emotional functioning
Working memory training increases cognitive control, thereby reducing the amount of amphetamine or cocaine used.
The objective of this study is to support consumers in their decision whether they want to perform a self-test or not. By providing objective information on self-testing, we expect knowledge levels of participants who have viewed the decision aid to…
We hypothesize that induction of trained immunity through BCG vaccination may improve host defence mechanisms of patients throughout the perioperative period.
1. Modafinil influences fatigue, cognitive functioning, and quality of life of LGG patients; 2. There is a correlation between (changes in) fatigue, cognition, and quality of life on the one hand, and functional connectivity in the brains of LGG…
We hypothesize that trimetazidine improves left ventricular diastolic dysfunction in HFpEF, by improving mitochondrial function and increasing myocardial energy content
Primary: Additional treatment with antibiotics in case of an exacerbation of COPD will not lead to a reduction in the severity and duration of exacerbations compared to treatment without antibiotics; Secondary: The relapse rate (defined as a new…
A combination of Lycopene and Vitamin E decreases PSA progression.
The combination of all three different learning techniques will elicit a stronger placebo analgesic effect than individual application for experimentally-induced thermal pain.
Indomethacin is known to be a strong inhibitor of ovulation in the spontaneous menstrual cycle. Therefore we assume that the use of indomethacin prior to follicle aspiration in IVF-treatment in the modified natural cycle (IVF-MNC) significantly…
Thiazolidinediones (TZD's, Pioglitazone) lower free fatty acids (FFA) in plasma via increased insulin sensitivity (=decreased lipolysis) in adipose tissue. The decrease in plasma FFA results in increased insulin sensitivity in skeletal muscle.…
It is expected that one week of supplementation with the study product will contribute to an improved immune response and to increased incorporation of EPA and DHA in white and red blood cells and plasma.
We hypothesize that treatment with a DPP-4 inhibitor will enhance the glucagon response to hypoglycaemia in patients with type 1 diabetes.