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We presume that reducing the fasting period by adding a carbohydrate drink 2-3 hours prior to surgery is a good and feasible option to decrease orthostatic intolerance and -hypotension. Moreover, the pre- and postoperative well-being is thought to…
To investigate whether the clinical outcome is similar after the implantation of the Resolute Integrity stent versus the Promus Element stent (non-inferiority test).
A Community One Health approach (bringing human and animal health together at the community level) improves disease surveillance efforts by Community Health Workers, health knowledge and behavior and physical health in study populations.
The primary research questions are: 1. To what extent does a 4 week ReHab-TOAT regime lead to improvement of arm function in chronic stroke patients with either a severely or moderately affected arm-hand? 2. To what extent is any improvement of arm…
Non-inferiority (defined as < 12.5% increase) of pooled buffy coat-derived PR platelet concentrates (PR-plasma-PCs) compared to plasma (plasma-PCs) in terms of clinical efficacy determined by WHO grade ≥ 2 bleeding complications.
1. Cysteine is an essential amino acid for newborn preterm infants; 2. Cysteine requirements change rapidly with postnatal age; 3. The change in cysteine requirement with age is based upon cystathionase activity; 4. Intestinal cystathionase activity…
We hypothesize that children who will follow this structured functional PRE strength training program will increase in muscle strength, which accordingly will lead to functional improvement in physical functioning, but with no negative effect…
We expect maternal hyperoxygenation in the presence of fetal distress during labor to reduce abnormalities in the fetal heart rate tracing and to reduce the need for assisted birth or a emergency caesarean section without severe maternal or fetal…
Sympatho-adrenergic and hypercoagulable activity are enhanced in patients with chronic heart failure, partially mediated by common functional beta2-adrenergic receptor polymorphisms. Non-selective beta-blockers down regulate sympathetic activation…
1. Cooling to 34, 34.5 or 35°C by means of a surface cooling device, started within 4.5 hours after the onset of acute ischaemic stroke and maintained for 24 hours in awake patients on a stroke unit is safe; 2. In awake patients with ischaemic…
Our hypothesis is that our gradually progressive protocol offers advantages with respect to the eccentric protocol based on the protocol of Alfredson (gold standard). We expect that, because this protocol is more individualized, less pain during the…
Athletes with longstanding groin pain recover faster and more completely if they are treated with specific pelvic stabilizing muscle training compared with regular care.
The healing of donor site wounds after split-skin grafting can be promoted by the use of one of five specific wound dressing materials as compared in this trial.
The primary aim of the study is to investigate patient characteristics that predict (differential) treatment response across MBT and ST. In addition, mechanisms of change in MBT and ST will be examined. Furthermore, the (cost-)effectiveness of MBT…
Participants in the intervention group will show a larger decline in household chaos than participants in the control group. As a result parenting quality in the intervention group will improve more than in the control group. Secondary hypotheses…
"De Nieuwe Toekomst" will empower female victims of intimate partner violence by making them financial independent which reduces the risk of intimate partner violence victimisation
We hypothesized that FFA loading could impair mitochondrial function and that the potency of FFA to disturb mitochondrial function and glucose uptake would depend on the degree of desaturation of the fatty acids infused.
The hypothesis states that the time tom complete an emergency airway with Cricath device is significant faster than with Quicktrach device, which will be studied on porcine cadaver models. In the second outcome, the hypothesis states that there is…
The hypothesis is that infants who receive the Infant Behavioral Assessment and Intervention Program (IBAIP) will be able to regulate themselves better and that disabilities will therefore be prevented or develop to a less serious degree.
Collaborative stepped care for anxiety disorders in primary care is cost effective compared with Care As Usual.