399 resultaten
Recently, (changes in) the gut microbiome (flora / bacteria) have been associated with obesity and insulin resistance, and other cardiovascular risk factors or atherogenic processes. Venous thrombosis shares these risk factors, probably by a shared…
In line with a previous pilot study we hypothesize that 3MDR will significantly decrease PTSD symptom severity in treatment resistant veterans with chronic PTSD in comparison with treatment as usual.
1. does pseudophakia influence intra ocular pressure (IOP) lowering effect of SLT? 2. the effect of SLT relies on an inflammatory reaction. Anti-inflammatory therapy is often used immediately following SLT, does this influence the IOP lowering…
1. Gatekeeper training is effective in enhancing relevant skills 2. Gatekeeper training will diminish rates of (attempted) suicides at regional level 3. The intervention is cost-effective relative to routine medical care
Surgical procedures are accompanied by high levels of distress and pain in the adult as well as the pediatric population. Music interventions have shown to reduce this anxiety and pain in adult populations. In this study, we will investigate the…
One-stop-shop concept, using real-time in vivo reflectance confocal microscopy as diagnostic tool is non-inferior to standard of care in the surgical management of new primary basal cell carcinoma
The primary aim is to determine whether a regular (hot-to-) cold shower can have a beneficial effect on immune function by reducing sickness absence. Secondary aims are to determine effects on quality of health and work productivity.
We expect maternal hyperoxygenation in the presence of fetal distress during labor to reduce abnormalities in the fetal heart rate tracing and to reduce the need for assisted birth or a emergency caesarean section without severe maternal or fetal…
To explore the effect of switching treatment from innovator infliximab (Remicade®) to infliximab biosimilar (Inflectra®, Remsima®) on efficacy, safety and immunogenicity in patients with rheumatoid arthritis (RA), spondyloarthritis (SpA) or…
The percentage of endoscopic resolution of Barrett’s esophagus at 3 months is non-inferior with two simple protocol versus the standard protocol.
Endoscopic resection of Barrett's neoplasia with the Captivator EMR device is effective and safe
Over 41% of the Dutch population is overweight, a known risk factor for a range of debilitating conditions. Modifying behaviours associated with overweight, such as eating rate, or the speed at which people consume food, could reduce overweight and…
Post-operative pain prevention with CSWI+PCA provides similar analgesia (measured by OBAS) in comparison to PCEA with shorter total operation time and shorter length of hospital stay.
Embryo selection using the Geri+ time-lapse system in combination with the Eeva Test (Early Embryo Viability Assessment) will increase the (cumulative) ongoing pregnancy rate of IVF and ICSI patients and thereby balance additional costs of TLM (time…
Determination of tacrolimus bioavailability after administration as rectiole
The aim of this study is to reduce antibiotic prescriptions by use of a clinical decision rule in febrile children suspected for CAP with unchanged outcome. Specific research questions are: 1. Does a decision rule reduce the use of antibiotics in…
A 3-month interactive cycling training is feasible and leads to improved executive functioning and physical fitness in early stage dementia patients. The association between physical activity and cognition is moderated by the presence of the ApoE4…
Double layer closure of the uterine scar using unlocked continuous running sutures reduces menstrual disorders and pain and subfertility in relation to niche development and increases QOL and improves sexual functioning.
Insulin-like growth factor I (IGF-I) is one of the key factors in the endocrine regulation of growth in preterm infants. After birth IGF-I levels quickly drop as the placental supply is suddenly disrupted, to then slowly be restored in preterm…