473 resultaten
The overall objective of this study is to assess safety of AG-348 and provide proof of concept of the efficacy of the drug in SCD patients. Based on currently available data, we hypothesize that the benefits of treatment of sickle cell disease…
In non-COVID-19 patients with pulmonary embolism a prevalence of up to 70% of concomitant symptomatic or asymptomatic deep venous thrombosis has been reported. Physicians experience an exceptionally high prevalence of pulmonary embolism in COVID-19…
Patients with new-onset or recurrent AF have an altered myocardial sympathetic activity. The quantification of sympathetic activity with 123I-mIBG scintigraphy, as well as its change over time after restoration of sinus rhythm, can be used to target…
Observational study
It is expected that the use of the MFB intervention will improve subjective cognitive functioning.
With this study we aim to disentangle mindfulness and placebo effects on pain. We investigate how decentering (a core component of mindfulness) and positive treatment expectations (a core component of placebo effects) interactively contribute to…
Similar or better fixation, migration and functional outcomes compared to other existing techniques
We hypothesise that the health behaviour of pregnant women is influenced by the measures to prevent the spread of COVID-19. It is not clear however, if it is positively affected (because of having more time, providing online options, creating a…
To determine the feasibility of the measurement protocol of a large prospective longitudinal study to describe the exercise capacity and physical functioning of critical illness survivors up to 5 years after discharge from the ICU.
We expect relatives to be satisfied about the last period of life after non-operative management of the hip fracture.
Deleayed umbilical cord clamping during elective caesarean sections has short and long term benefits for the neonate, whilst not increasing the risks for mother and neonate.
eNose is able to detect metastases of CRC with a sensitivity of at least 70%
Colloid Oncotic Pressure as indicator of hemodilution in cardiac surgery with cardiopulmonary bypass
The addition of albumin or gelofusine in the predominantly crystalloid prime is beneficial for COP compared to the crystalloid only prime in cardiac surgery setting with cardiopulmonary bypass.
Successful implementation of a patient decision aid regarding breast cancer follow-up care facilitates shared decision-making and results in quality improvement in breast cancer follow-up care.
It is hypothesised that both laser devices will be highly comparable
Implant survival rate of 90% or higher
We will test whether each component specifically reduces the risk factor it aims to target: Does component A (relational perspective based child-led play) improve the parent-child relationship, and not coercive parent-child interaction cycles or…
Parents who receive the two-day EMDR treatment will report significantly lower trauma scores and psychological comorbidity scores post-treatment compared to the wait-list group.
A minimally invasive endoscopic step-up approach remains preferable over the surgical step-up approach to treat infected (peri)pancreatic necrosis. In the long term we expect no differences in the primary endpoint composite of death and major…
We think that not every patient with a paracetamol intoxication might need the high dose of acetylcysteïne antidote we are used to dose in the Netherlands