318 resultaten
Rationale: Antibiotic resistance is a growing problem worldwide with considerable costs. It is mainly driven by inappropriate use. It is necessary to look for measures that improve prescribing in antibiotics and that stimulate both health…
A recent Genome Wide Association Study (GWAS) identified novel risk loci for type 2 diabetes including EXT-2. This gene codes for exostosin, which is an enzyme involved in the elongation of heparan sulfate, a glycosaminoglycan present in all cells…
The control of voluntary movement involves different parts of the central nervous system. The involvement of the cortex in the control of movement is not always incorporated in research on motor control. In this study we will use system…
Primary sclerosing cholangitis (PSC) and primary biliary cirrhosis (PBC) are relatively rare liver diseases that in most cases lead to liver failure in 10-20 year. Nowadays, both diseases are regarded as immune dysbalance disease entities, but in…
This study may result in optimization of health care for children with irritable bowel syndrome. If this study shows that home-based therapy is comparable in effectiveness with hypnotherapy by a therapist, it could become therapy of choice in the…
1. SNS is more effective than BOTOX® 100 U as assessed by the difference between treatment groups in the proportion of idiopathic OAB patients with a positive treatment response on the Patient Perception of Bladder Condition (PPBC) at Week 12…
The Psycho-Education/Coping Skills Training is effective in reducing the negative consequences of stigma in people with a severe mental illness: 1. Increasing quality of life; 2. Improving social functioning; 3. Reducing needs for care.
We hypothesis that early surgical intervention results in less pain over the study period and is more cost-effective than the optimal current step-up practice.
Children in the intervention conditions will be more likely to have negative attitudes and norms towards smoking and alcohol than children in the control condition.
Depression is a major health problem in glioma patients, with emotional, cognitive and physical sequelae. Depression in these patients may be associated with increased morbidity and even with poorer survival. In addition, depression is the most…
The hypothesis to be tested is the relationship between the number of blood transfusions, serum ferritin and transferrin saturation level and MRI T2*Heart, T2*Liver.
There is no difference between treatment with DMSO and prednisolone in reduction of inflammatory signs and symptoms as measured with a validated compound score (ISS) on the severity of CRPS-1.
iFABP can be used as a primary diagnostic tool to detect and exclude mesenteric ischemia.
We hypothesize VOC signatures to discriminate between critically ill patients: 1. With and without sepsis; 2. With or without pneumonia; 3. With a gram positive or gram negative infection; 4. With and without organ failure, including: A. Acute lung…
Intentional continuous shallowing of the anterior chamber (ICSAC) does not harm the corneal endothelium.
A study of 2B3-101 in patients with solid tumors and brain metastases or recurrent malignant glioma.
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It is expected that dopaminergic antagonism by haloperidol 2mg or 3mg wil result in specific inhibition of both bias and disengagement related activity as measured by EEG in combination with computertasks. Specifically, we expect that, dopamine…
Oral exposure time and energy content of the gastric load both effect subjective feelings of satiety, gastric emptying rate and subsequent food intake. A longer oral exposure time and a high gastric energy content would both increase subjective…
Knee Joint Distraction in comparison with Total Knee Prosthesis in treatment of knee osteoarthritis.
The clinical effect of Knee Joint Distraction (determined by WOMAC) is not (clinically relevant) different from Total Knee Prosthesis at two years post treatment (equivalence hypothesis).
Compared to treatment as usual adding direct session feedback in the treatment of a mixed diagnostic group of patients in an acute psychiatric crises improves outcome at symptom level, well being, patients’ satisfaction, and drop out.