318 resultaten
Intensive counselling from a practice nurse in combination with varenicline (intervention group) will be significantly more effective in smoking cessation than a short quit smoking advice from a general practitioner in combination with varenicline (…
The aim of the meta-analysis is to investigate the early predictive value of migration measured by RSA 2 years post-operatively for revision for aseptic loosening of the acetabular component in THA and to compose migration thresholds for safe and…
In this randomized crossover pharmacokinetic study we will investigate the effects of cytochrome P450 enzyme induction (including CYP3A4, CYP2C and CYP2D6) by rifampicin on the metabolism and plasma pharmacokinetics of tamoxifen and its metabolites…
Primary Objective: In this trial we will investigate the efficacy of BVR using best responder criteria in patients with severe heterogeneous emphysema compared to usual care. Secondary Objective: Economic evaluation: Estimation of costs of BVR…
The addition of inspiratory muscle training to a general exercise training program improves inspiratory muscle strength, exercise capacity, health related quality of life and participation in daily physical activity in patients with COPD suffering…
ICG alone without being absorbed to albumin can be used for near-infrared fluorescence SLNB in cervical cancer patients.
1. Participants in the experimental condition have more favourable outcomes on the long-term (1 year follow-up) than participants in the control condition. Outcome measures are physiological (e.g., weight), behavioral (e.g., dietary behavior), and…
What are the causes of interval colorectal cancers? Are they the result of technology related or biology related factors? 1. Interval colorectal cancers (CRCs) are more common than expected; 2. Interval CRCs are characterized by a different…
1. The diagnosis of celiac disease can be established by positive antibody tests in combination with elevated plasma I-FABP levels that recover in response to gluten elimination without obtaining intestinal biopsies in patients with HLA risk…
Cancer is a common disease with serious consequences for patient’s physical and psychosocial functioning. These consequences may last for a long time, even after completion of the curative treatment. To overcome cancer-related problems and to…
In this trial the efficacy and toxicity is tested of treatment with lenalidomide and rituximab (arm A), and lenalidomide, rituximab and bendamustine (arm B) in patients with relapsed follicular lymphoma (FL).
We hypothesize that doxycycline and minocycline will be equally effective for the treatment of papulopustular rosacea.
Does addition of lenalidomide to chlorambucil and rituximab result in better response rates with acceptable toxicity.
N/A
Main question: What is the value of the propensity for reinvestment (measured by the Movement Specific Reinvestment Scale) in predicting the functional mobility (measured with he Rivermead Mobility Index) of stroke patients after 15 weeks of…
The aim of this study is to validate the Dutch versions of the PainDETECT questionnaire PD-Q and the ‘Douleur neuropathique en 4 questions’ (DN4) for use in primary and specialist medical care settings for patients with LBP and NSP and patients with…
The depression prevention program ("Op Volle Kracht") will be delivered by teachers in the school curriculum in schools with adolescents from high-risk background. It is expected that adolescents who receive the interventions will show…
We hypothesize that CTX patients, when untreated for a short period, differ from matched healthy controls in the response to a test meal. CTX patients are expected to have lower postprandial GLP‐1 and insulin levels with higher plasma glucose and…
For patients with breast cancer who are not applicable for breast-saving treatment (because of tumor characteristics), who prefer an amputation or who undergo a prophylactic amputation an immediate breast reconstruction is a standard offer. A…
We hypothesize that autotransfusion of leukocytes and lipid depleted cell saver blood leads to less prone inflammation and coagulopathy after cardiac surgery. We expect a less activated (cell derived-microparticle poor) and a more ‘pure’ (hemolysis…