130 resultaten
Many hypotheses within the overarching study framework (see summary) related to the main outcomes.
OR workflow for surgeons needing to interact with the laparoscopic equipment during surgery is optimized using TedCube© in combination with the Myo™ gesture control armband and/or a wireless headset.
A safe RP2D of Vyxeos®/CPX-351 in combination with clofarabine can be identified in this phase 1b study.
We hypothesize that in critically ill patients, measuring the anti-factor-Xa randomly in a 3 to 5 hours timeframe, may introduce a significant variation in the measured anti-factor-Xa and can seriously underestimate the real peak anti-factor-Xa.
The hypothesis is that the injury rate, severity and burden of injury over one-season is lower among youth volleyball players using ‘VolleyVeilig’ than among youth volleyball players not using ‘VolleyVeilig’ (volleyball as usual).
A 12 weekly computer-tailored coaching program reduces sedentary behavior. Perceived bodily pain, mental health, vitality, stress, and performance are expected to lower by the means of reduced sitting time.
Trifluridine is primarily metabolized through degradation by thymidine phosphorylase to the inactive metabolite 5-(trifluoromethyl)-uracil (FTY) without any involvement of the cytochrome P450 enzyme system. The primary route of excretion of…
Exploratory study investigating the efficacy of the currently recommended dosing regimen of ciprofloxacin prophylaxis in patients treated for haematological malignancies.
The hypothesis to be proved in this study project is: “first attempt success ratio of peripheral intravenous catheter placement will increase up to 90% in adult patients when a Venflon™ Pro Safety with BD InstaFlash™ Needle Technology is inserted,…
We hypothesize that subjects with NASH produce more ethanol after a mixed meal tolerance test than subjects with a healthy liver after receiving a infusion with fomepizole.
Biomarkers for predicting disease severity in emergency department patients with suspected infection
Novel biomarkers can aid in the early identification of sepsis, and can be useful for risk stratification at the ED in patients with a suspected infection.
We expect changes in each of the three tasks, with less words remembered (15 word test), a larger Simon effect (Simon task) and slower performance (TMT) in the repeated assessment compared to the first assessment. We also expect changes in each of…
It is an observational study, no null hypothesis has been formulated. The purpose of StEM is to understand the expectations, needs, experiences, choices and decisions of pregnant women and women who recently gave birth in the Netherlands, recording…
Chemodenervation by lidocaine of the m. vastus intermedius and the m. rectus femoris improves gait pattern in stroke patients presenting a stiff knee gait.
High-resolution ultrasound (HRUS) is a quick and cost-effective technique to study the morphology of peripheral nerves. Sonographic characteristics of plexiform neurofibromas and MPNST have been described in the literature. Recently, a pilot study…
Main question: Is Theraplay an effective treatment method for children with ASD and what is the effect of treatment with Theraplay on their parents? Prior RCTs proved that Theraplay leads, among other things, to a decrease in internalizing problem…
Awake craniotomy improves safety and efficacy during surgery for glioblastoma in eloquent areas
1) The checklist 'Attune & Stimulate' is a valid instrument to assess the arousal level of clients with SID. 2) Caregivers who are randomized to the intervention group that is instructed to use the A&S-checklist attune…
Breast cancer is the most common type of female cancer worldwide. Early detection has proven to have a positive influence on the prognosis and survival rate. An important aid in the detection and diagnosis of breast cancer is the use of medical…
Primary hypothesis: Octane concentrations in exhaled breath facilitate early detection of ARDS in ICU patients. Secondary hypotheses: - ARDS resolution is associated with a decrease in octane in exhaled breath. - Additional biomarkers of ARDS can be…