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Minimization of maintenance immunosuppression early after renal transplantation.

Chronic allograft nephropathy is the main cause of long-term renal transplant failure. The pathogenesis involves amongst others calcineurin inhibitors. We performed a multicenter randomized trial to study the effects of withdrawal of ciclosporin (…

Lipid-induced insulin resistance.

Administration of a lipid emulsion consisting of long-chain triglycerides (LCT-trial) in non-trained individuals, will induce insulin resistance due to increased DAG accumulation and subsequent activation of the PKC pathway in skeletal muscle.…

Lipid-induced mitochondrial dysfunction in type 2 diabetes.

Does lipid accumulation in skeletal muscle and the heart effect mitochondrial function in relation to insulin resistance?

Catheter ablation versus Amiodarone to pRevent Future shock Episodes in patients with a defibrillator and a history of a myocardial infarction.

It is assumed that recurrence of appropriate ICD shocks is 30% in the Amiodarone group and 16% in the Ablation group.

TightRope AcromioClavicular Study; TRACS.

Acute Rockwood type 3 AC-luxations will have a better function after operative treatment with the artroscopic TightRope technique than patients treated conservative.