12909 resultaten
We expect the protein synthesis rate in (avascular) femoral bone proximal to the fracture to be lower when compared to healthy femoral bone.
SLE patients show a decreased humoral immune response to influenza vaccination, as compared to healthy controls. Furthermore the use of immunosuppressives is of influence on vaccination immunogenicity, it has been demonstrated that the use of drugs…
There is clear medical need in pediatric high-grade MDS and JMML to control disease pre-SCT without the disadvantages associated with intensive chemotherapy. So far no agents have been successfully applied in this window, or are specifically…
With implementation of the AWR we expect a reduction in the total amount of radiographs requested, without missing any clinical relevant fractures. We also expect a reduction in overall waiting times at the ED and a total amount of cost savings…
Both two transition management interventions will be effective in the reduction of the school transition problems of children with ASP. We have no hypothesis about which intervention will be most effective in the reduction of childhood…
The Untire app will create awareness by proving psycho-education and will give insight in ones’ energy levels, ones’ thoughts and behaviors in relation to energy levels and provides exercises that help users to challenge ineffective thoughts and…
A two month distraction period results in similar clinical beneficial effects as a three month distraction period.
The hypothesis to be tested is that arm B is tolerable and that the outcome in arm B is better than in arm A.
6MP treatment in pediatric ALL patients can be improved by developing a pediatric oral drinking solution of 6MP, assessing its bioequivalence, and -when successful- introducing the new formulation nationwide.
The rate of unintended events and avoidable harm for elderly hip fracture patients can be reduced by the introduction of three integrated interventions directed at the structure of the handover process, the role of the patient in the care process…
Mechanical bowel preparation (MBP) is common practice in elective colorectal surgery. In recent literature the value of MBP is subject of discussion. This non-inferiority, randomized study evaluates the value of MBP before colorectal surgery.
The hypothesis to be tested is that the outcome in arm B is better than in arm A.
For patients with metastatic or local-regional unresectable esophageal carcinoma there is no alternative treatment. In this trial it is studied whether combination chemotherapy with oxaliplatin and capecitabine prolongs survival and improves quality…
Binocular patching in combination with posture adherence is superior to posture adherence alone in achieving visualization of the superior fundus quadrants following a vitreous hemorrhage.
To study the effectivity of different retreatment radiotherapy schedules for painful bone metastases.
The primary hypothesis of the study is that a well-being intervention (‘This is your life’) offered to bipolar disorder (BD) patients in remission in addition to usual care (CAU) is more (cost-)effective than CAU only.
The primary research hypotheses are: 1. Patients who follow the Onco-Move program will achieve better physical fitness levels, as assessed by objective performance tests, and will report less fatigue than patients in the usual care control group; 2…
To evaluate the response to adalimumab treatment in TNF-alpha blockade naïve patients and patients who failed prior other anti-TNF-alpha treatment and to understand the mechanisms underlying the clinical response to TNF-alpha blockade.
This is a superiority trial testing the hypothesis that adenoidectomy is more effective than a watchful waiting strategy in children with recurrent upper respiratory tract infections.
Good Inter-observer agreement for important markers such as bowel wall thickness and Doppler activity