205 resultaten
Our hypothesis is that growth hormone threatment in adults with Prader-Willi Syndrome will improve their metabolic and cardiovascuar health, thereby resulting in a reduced mortality.
The post-prandial rise in total amino acid, proline and glycine concentration following a single bout of resistance exercise will be the highest in the 20 gr whey combined with 10 gr collagen compared to all other test drinks
Improvement of favourable outcome by consecuetive treatment of tranexamic acid before aneurysm treatment with switch to acetylsalicylic acid short before start of treatment and continued for two weeks.
The study will assess drug-induced change in performance in divergent thinking and goal-directed behaviour when comparing psilocybin to placebo, before and after an induction of stress. Additional study parameters include frontal-subcortical…
An injection of 1cc PRP, taken and processed directly from the patient, in a lumbal disc with or without anular tear, without modic, significantly improves pain and functionality.
Overall, diagnostic accuracy will be lower on subjected-to-bias than on not-subjected-to-bias cases, but the difference in accuracy will be smaller in the group of physicians with higher knowledge of critical diagnostic features. Overall, the…
Major depressive disorder (MDD) is projected to rank second on a list of 15 major diseases in terms of burden and is highly recurrent in nature. Accordingly, efforts to reduce the disabling effects of this chronic condition should shift to…
Although vitamin D is well known for its function in calcium homeostasis and bone mineralisation, several studies have shown an effect on pulmonary function and incidence of airway infections. Vitamin D deficiency is a common problem in patients…
We hypothesize that transfusing red cells with a storage time of 2 to 8 days reduces the incidence of nosocomial pneumonia in ICU patients.
Acute challenges with cocaine and cannabis will induce two opposing dopaminergic states in the brain. Cocaine will stimulate dopamine release leading to hyperdopaminergia whereas cannabis will reduce central dopamine levels resulting in…
We hypothesize that induction of trained immunity through BCG vaccination may improve host defence mechanisms of patients throughout the perioperative period.
Let µT denote the mean value of the composite IBS-SSS score under treatment with the active / GOS and µP denote the mean value of the composite IBS-SSS score under placebo, then the primary two-sided hypothesis to be tested is: • H0: µT - µP = 0 (i.…
If COMET increases the saliency of positive autobiographical memories, then memories that are activated during COMET (relative to no intervention control) should show an increase over time on all primary outcome measures, irrespective of medication…
Triclosan coated sutures might have an positive effect on wound healing and thus can improve scar quality.
A single bolus EPO administered just before a primary PCI for a first acute myocardial infarction will increase left ventricular function after 4 months.
It is hypothesized that an intervention with the KPR could decrease pelvic tilt, as measured using clinical leg length difference and the ASIS-PSIS angle, for 50% or create a crest height difference smaller than 0.5 centimeters in patients with non…
It is expected that dopaminergic antagonism by haloperidol 2mg or 3mg wil result in specific inhibition of both bias and disengagement related activity as measured by EEG in combination with computertasks. Specifically, we expect that, dopamine…
Fluoxetine and movement observation are able to increase cortical activity after stroke