146 resultaten
The systemic treatment of rheumatoid arthritis with anti-TNF-a is very successful. In a number of case reports varying success rates of intra-articular injections with the TNF-a blocking agent infliximab have been reported. In this study we want to…
The hypothesis is that increasing energy and protein intake in these children will stimulate the rate of protein synthesis, decrease the rate of (muscle)protein breakdown, lead to increased net protein accretion, avoids weight loss and promotes…
Higher doses of statins will result in additional improvement of the diabetic lipid profile.
Antioxidants or anticytokines may suppress the autoimmune reaction in orbital tissues in Graves' orbitopathy patients. Nul hypothesis: selenium and pentoxifilline are as effective as placebo in mild Graves' orbitopathy.
The primary objective of this study is to determine whether treatment with statins reduce the progression of aortic stenosis in young adult patients with congenital aortic stenosis.
Comparison of pharmacokinetics, pharmacodynamics, efficacy and safety of recombinant asparaginase(ASNase) versus Asparaginase medac during induction treatment in children with de novo ALL and to demonstrate that any clinical important difference to…
The hypothesis is that MS is a T cell-mediated autoimmune demyelinating disease of the central nervous system (CNS). In order to start immune reactions in the CNS, myelin antigen need to be presented on the surface of antigen presenting cells (APCs…
Asthma reduction at age 6 is possible with inhaled corticosteroids in children of 1-4.5 years old with a familial predisposition for asthma in the first degree, who develop wheeze symptoms.
Accumulating data in the literature support an important role for serotonin, in the neurobiology of CFS. Neuroendocrin and neuropharmacological studies point to an up-regulated or hyperresponsive serotonin system. Positive reports of the use of…
To continue a risk-adapted stratification of therapeutic intensity, incorporating response to pre-operative chemotherapy, in all children with Wilms tumour and other renal tumours of childhood. To test the treatment hypothesis that doxorubicin is…
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VLBW infants may be susceptible to glutamine depletion as nutritional supply of glutamine is limited in the first weeks after birth. Glutamine depletion has negative effects on functional integrity of the gut and leads to immunosuppression. This…
For women with a singleton at term fetus in breech presentation, what is the success rate of external cephalic version (ECV) with a calcium antagonist nifedipine compared to version without medication?
Administration of brimonidine eye drops in patients with AION reduces loss of vision.
We hypothesized that patients treated with Methotrexate (MTX) will have less duration and less severe arthritis, will not or less evolve into RA, will develop less radiographic progression in joint damage, and are more likely to go into remission.
An early intervention with low-dose aspirin in asymptomatic diabetic subjects attenuates progression of atherosclerosis, by decreasing inflammation and coagulation.
Protocol I: 1. Risperidone will be effective in reducing impulsive aggression, agitation, self-injurious behavior and troublesome repetitive behavior associated with autism and related disorders; 2. Risperidone will result in sedation (transient…
That minimal invasive laparoscopic surgery and/or multimodal patient care (fast track) can prevent post operative ileus and/or improve post-surgical gastrointestinal motility compared to open surgery and/or conventional patient care.
Major null hypotheses, H0: As compared with a plant stanol ester free diet, a stanol ester enriched diet: does not change serum concentrations lipids and lipoproteins both when given alone or in combination with a low-dose (10 mg/day) simvastatin…
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