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EDB for Ménière's disease

We hypothesize that the number of patients without vertigo spells at 12 months follow up will be higher in the group that has undergone EDB than in the decompression group.

A randomized study on probiotics and their effect on vitamin K2 status

We hypothesize that probiotics with vitamin K2 producing properties can improve vitamin K status, which will eventually reduce the risk of coronary calcification.

Intervention With a GABA Supplement in Prediabetics

We hypothesize that GABA could improve glucose tolerance and cardiovascular health after long-term supplementation

Enrichment randomized double-blind, placebo-controlled cross-over trial with PHEnytoin cream in patients with painful chronic idiopathic axonal polyNEuropathy

The main objective is to evaluate the efficacy and safety of phenytoin cream in patients with neuropathic pain due to CIAP

Compairing two cognitive aids

Which design of cognitive aid (emergency manual) is easier to use and results in less missed critical actions during anesthetic emergencies

PENG vs placebo 'sham' block RCT

The pericapsular nerve group (PENG) block is superior to placebo 'sham' blocks in hip arthroplasty surgery in reducing patients pain scores (Numeric Rating Scale of 0 to 10), on the day of surgery

Optimaal gebruik van Botuline toxine voor efficiënte behandeling van chronische anale fissuren

Botulin toxin driven treatment ylieds the highest efficacy when injected into the external anal sphincter.

The MEtformin-LIfestyle in Antipsychotic users trial

We expect that metformin in combination with lifestyle interventions reduces Antipsychotic induced Weight Gain compared to placebo in combination with lifestyle interventions.

PENG vs placebo 'sham' block RCT

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Methylphenidate for ADHD in Smith-Magenis syndrome

We hypothesize that methylphenidate improves ADHD manifestations in children and adults with SMS.

Doxapram in preterm newborns

This study hypothesizes that doxapram will protect preterm infants from both invasive ventilation (and related lung disease) and apnea of prematurity related hypoxia (and related impaired brain development).

Deep inferior epigastric perforator flap breast reconstruction with or without inguinal lymph node transplant for treatment of breast cancer related arm lymphedema:
A multicenter randomized controlled trial

combining a standard DIEP-flap breast reconstruction (BR) with an inguinal lymph node transplant will lead to an improvement of the BCR

The HipPOCUS-trial

The sensitivity of POCUS, performed by emergency physicians is ≥ 90%

Alkaline phosphatase for reducing systemic inflammatory response syndrome (SIRS) in patients with Sars-CoV-2 infection and acute respiratory insufficiency (COVID 19)

Our hypothesis is that critical ill COVID-19 patients suffer more from their own immune response against the virus, than from the viral infection itself. Alkaline phosphatase (RESCAP®) has proven to reduce SIRS reactions by neutralizing the…

Vasco da Gama

We hypothesize that long-term continuation of macrolide maintenance therapy after at least 1 year of treatment in COPD patients results in a prolonged time to next exacerbation compared to withdrawal of azithromycin macrolide treatment

A multicenter randomized controlled trial assessing and comparing long-term scar quality after micrografting versus mesh grafting of deep dermal burns

Our hypothesis is that treatment with micrografting, when compared to conventional meshed graft, will result in a better scar quality and smaller donor site size.

Sub(acute) Profiling of 2C-B Versus Psilocybin

2C-B generates distinct acute and subacute effects from Psilocybin and placebo

Different trajectories for people with acute neck pain: associations with biological, psychosocial and treatment-related factors.

We hypothesize that there will be different trajectories related to recovery in acute neck pain patients and that several biological, psychosocial and treatment related factors are associated with distinct trajectories. We hypothesize that the…

A Randomised controlled Trial on the Effect of local analgesia for pain relief after Minimal Invasive Sacro-Iliac joint fusion

Sacroiliac joint infiltration with bupivacaine 0.25% is superior to placebo in reducing post-operative pain.

BCG vaccination for healthcare workers in SARS-CoV-2 pandemic

BCG vaccination may induce (partial) protection against susceptibility to and/or severity of SARS-CoV-2 infection. This will lead to reduced workplace absenteism under health care workers taking care of patients with COVID-19