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We hypothesize that a treatment algorithm that is based on a simple validated measure of health status (CCQ) improves quality of life (as measured on a separate scale) and other classical COPD outcome measurement parameters such as exacerbation…
Prolonged antibiotic treatment of patients diagnosed with presumed PLD (as endorsed by the international ILADS guidelines) leads to better patient outcome than short-term treatment as endorsed by the Dutch CBO guidelines.
The TENLEP Trials proposal builds on the findings of the INFIR Cohort Study and the recommendations of the NLR-funded international Workshop on Neuropathology in Leprosy in the Netherlands in 2007. At this workshop, several key research questions…
Based on its general pro-hemostatic potential, prothrombin complex concentrate may be effective in (completely or partially) reversing the anticoagulant effect of the new antithrombotic agents Dabigatran and Rivaroxaban.
In the present study we will investigate the pharmacokinetic profile of three doses of sublingual testosterone, and measure subjective and physiological measures of sexual functioning in healty premenopausal women. The lowest effective dose of…
To determine whether doubling the dose of corticosteroid injections in the treatment of arthritis in knee joints is more effective, both in number of responding patients and in duration of response (pain relief).
A positive effect of the investigational product on the intestinal microbiota of healthy Asian toddlers is expected.
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Our hypothesis is that the extravesical technique reduces the incidence of PCN placement, and urological complications.
Type 2 diabetes patients frequently suffer from physical deconditioning and vascular disease. Although the exact mechanisms are unclear, microvascular changes and endothelial dysfunction appear to inhibit the oxygen transport and uptake in…
BB3 will improve kidney function in the immediate post-transplant period in patients who have received a DCD kidney transplantation.
Patients with a wrist trauma represent a substantial part of the patient population at the Emergency Department. Most hospitals routinely carry out a radiological examination of patients following wrist trauma to exclude a distal radius fracture.…
A positive effect of a Growing Up Milk with added prebiotics or prebiotics and LCPUFA on the intestinal microbiota of toddlers.
The hypothesis is that testosterone supplementation improves functional mobility, quality of life, body composition, cognitive function, aortic stiffness and cardiovascular risk factors, and bone mineral density compared to placebo.
The simplified HALO360 ablation regimen result in an easier and faster ablation procedure, while maintaining efficacy and safety.
A four day adminstration of N-acetylcysteine (3600 mg/day) will reduce craving, withdrawal symptoms and the bias towards nicotine related cues compared to a four day administration of placebo in nicotine dependent subjects.
ICG alone without being absorbed to albumin can be used for near-infrared fluorescence SLNB in breast cancer patients.
When insufficient amounts of analgesics have been infused during anestesia, the BIS response a surgical stimulus will be larger and the BIS and EMG display increased variability (CVI).
We hypothesize that this simplified HALO90 ablation procedure results in an easier and faster ablation procedure, while maintaining efficacy and safety.
Pulse oximetry is a non-invasive method allowing monitoring of the oxygen saturation of a patient. For many years now, it has been used in secondary care with great success. Recently, it is noticed that pulse oximetry is used more often in the…