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Stop or Go? Relapse prevention training with guided tapering of antidepressants during pregnancy. A pragmatic multicenter RCT to investigate risk and benefits for mother and child.

1) Tapering of SSRIs with added preventive cognitive therapy (CT) increases the risk of clinically relevant maternal relapse of depression in excess of [absolute] 15% compared to continuation of SSRIs. If rejected, then discontinuation is deemed non…

Comparison between acute restoration of normal sinus rhythm and a wait-and-see-approach until spontaneous restoration of normal sinus rhythm in patients with acute symptomatic atrial fibrillation (ACWAS-trial).

A Wait and See-approach is non-inferior on percentage of patients in sinus rhythm at 1 month as compared to acute cardioversion, but leads to a higher quality of life and less costs.

A clinical comparison of two different retention systems for implant supported ear prostheses

A magnet-retained ear prosthesis is equally or more satisfactory compared to a bar/clip retained ear prosthesis

A study to evaluate the pain and anxiety reducing effects of music during gynecological outpatient procedures.

There is some evidence that patients tend to experience less pain and anxiety while listening to music during an office procedure like colposcopy, hysteroscopy of endometrial ablation. The aim of this study is to prove a significant reduction of…

Online training to reduce anxiety and depressive symptoms

The aim of the current study is to test whether online training of a positive attentional bias and/or working memory capacity can reduce anxiety and/or depressive symptoms in adults with heightened emotional symptoms.

Effect NMES on physical performance in frail elderly during hospitalization.

NMES will reduce the detoriation of the m. quadriceps during admission in the hospital compared to functional fysiotherapy.

TropicALL study

Primary objective: To assess the efficacy of thromboprophylaxis with high prophylactic dose LMWH as compared with standard care without systemic thromboprophylaxis in children treated for primary ALL. Secondary objectives: 1. To assess the safety…

Veranderingen in plaspatroon en kwaliteit van leven bij kinderen met plasproblemen die een behandeling met Botox krijgen.

To assess the change in voiding pattern and quality of life in children who receive BoNT-A treatment in a prospective setting.

Intermitterende sacrale neuromodulatie bij idiopathische overactieve blaas.

To elongate the service life of the implantable neurostimulator while achieving a minimal improvement of 50% of the symptoms of overactive bladder compared to baseline.

Behandeling van Obstipatie bij Kinderen

We expect paediatric pelvic physiotherapy in addition to conventional treatment to be more (cost)- effective than conventional treatment alone, after 8 months follow-up.

Cost-effectiveness of minimal invasive spinal fusion compared to open fusion for patients with spinal stenosis with neurogenic claudication or radicular leg pain.

Minimal invasive fusion results in a longer time spent in satisfactory symptom state (based on the ODI being below 20) than open fusion of the lumbar spine in patients with one- or two-level spinal stenosis and instability, associated with…