285 resultaten
In frail older preoperative patients with polypharmacy, evaluation of medication, with the aid of the STRIP assistant, will identify potentially inappropriate medications and potentially prescribing omissions. Optimization of pharmacotherapy will…
Mood monitoring using smartphones has no clinically relevant effect on low mood.
Considerable health efficiency gains can be achieved by the substitution and optimization of usual perioperative care by means of e-health and ICT.
Objectives: • To determine the RP2D of crizotinib in combination with vinblastine • To determine the RP2D of crizotinib in combination with temsirolimus • To determine the safety and preliminary activity of single-agent crizotinib in ALK, MET or…
Prosthetic Heart Valve (PHV) endocarditis is complicated by peri-annular extension (abscesses/mycotic aneurysms) in up to 50% of patients and has an in-hospital mortality of approximately 30%. However, with current standard imaging tools such as…
Because of the impact of chronic abdominal pain in children and the long term prognosis with impressive consequences for the life of the patients and for the society, it is important to aim at optimal therapy. Standard therapy is rather ineffective…
Rationale: Measuring the serological effects of the different vaccinations (immune surveillance) is an important tool for the evaluation of the National Immunisation Programme (NIP) by providing insight in the immune status of the population, by…
It is hypothesized that, as a result of the existing interventions 'Een Gezonde Start' (English: 'A Healthy Start') and 'PLAYgrounds' child care providers will have an increased level of confidence in supporting…
Aim: Our project aims to assess the effects of including second best options in risk communications that currently only contain best options, by studying two cases: smoking cessation versus e-cigarette use, and full versus partial vaccination.…
PK and PD effects of JNJ-61393215
Divergent Low Level Laser Therapy as novel treatment for oral mucositis in pediatric cancer patients
What is the effect of divergent LLLT on the number of days of mucositis > grade 1?
With the quantification of circulating tumor DNA treatment response assessment will improve in metastatic prostate cancer patients.
In order to support allergy research, well-defined and validated methods for measuring allergens are needed. Currently, there is no such method sensitive enough to detect Ara h6 in the circulation after peanut consumption. Therefore, developing this…
Tailored exercises lower the injury risk significantly compared to regular exercises in elite youth football players with a high injury risk
A single exercise bout with a minimum duration of 10 minutes and a moderate to vigorous intensity level has small but positive effects on cognitive performance in children. These acute effects on cognitive performance are thought to be mediated by…
Patients treated with ziprasidone reveal fewer negative symptoms on the PANSS negative symptoms sub-scale and/or better scores on the CGI therapeutic effects sub-scale (CGI-TE) than patients treated with low-dose conventional antipsychotics (5 mg/…
No orthosis is not inferior to an orthosis in terms of reported pain after dorsally fixated thoracolumbar fractures.
The primary aim of this study is to evaluate NET in SMI patients with comorbid PTSD associated with repeated interpersonal trauma whether: a) the PTSD symptoms changes and b) changes occur in the present SMI symptoms, care needs, quality of life,…
The aim of this study is to assess whether the use of the IncoSense Smart leads to improvement in efficiency of incontinence care, better quality of life of the clients and reduction of the cost.