285 resultaten
We expect to demonstrate that ctDNA can be reliably detected in patients with perihilar cholangiocarcinoma.
Investigate if Chronic Fatigue Syndrome patients show signs of neuroinflammation, compared to Q-fever Fatigue Syndrome (QFS) patients and healthy neighbourhood controls.
We postulate that faecal microbiota transplantation (FMT) from obese donors in patients with cancer can improve satiety (appetite) and subsequently nutritional status. Secondly, FMT might restore the gut barrier function and hence reduce systemic…
Prolonged exposure to supraphysiological levels of GH and/or IGF-1 induces activation of innate immune responses, which might contribute to the long-term CV morbidity in acromegaly patients.
The primary hypothesis of this study is that it is possible and effective to treat trauma using Imaginary rescripting (IMRS) in reducing trauma-related complaints in severely underweight eating disordered patients. The secondary hypothesis is that…
- surgical treatment for CMC OA is effective in terms of pain, function and satisfaction - There is a relatively large group of patients with significant residual pain and functional impairment or deterioration of their complaints - Baseline factors…
Phase I testing of ABP-700 alone and with remifentanil co-infusions have shown the ability to produce consistent dose dependent sedation effects with conditions favorable for procedural care including minimal involuntary muscle movement, stable…
Pelvic floor muscle training supported by vaginal and abdominal biofeedback, serious games and a web-portal is non-inferior to pelvic floor muscle training alone.
1. It is common to stratify a dataset on gender and age when identifying frequent attenders within general practice. However, this could lead to an oversampling of patients with chronic diseases, e.g., cardio-vascular disease or diabetes. We…
The primary objective is to determine whether JWH-018 can be safely administered in healthy volunteers in doses up to 3 mg. Therefore participants will be continuously monitored by a medical doctor and vital signs, laboratory clinical safety and…
Wheelchair mobility skills training and wheelchair fitness training will both increase the level of physical activity in wheelchair using children and adolescents. Wheelchair fitness training prior to wheelchair mobility skills training will show a…
Type 2 diabetes is associated with an increased cardiovascular risk. Besides metformin, a new treatment strategy is oral SGLT2 inhibition (dapagliflozon), Although two recently published, first-in-class cardiovascular outcome trials (EmparegMPA-REG…
To determine the concordance between the ex vivo anthracycline sensitivity test and in vivo response to anthracycline-based NAC. Also, optimal cut-off values for the ex vivo anthracycline sensitivity assay are determined to carefully predict in vivo…
Structured follow-up from primary care will effect patients‘ satisfaction with care and health care utilisation.
This is a prospective pivotal trial to study the safety and efficacy of a PCL-based bulking agent (UrolonTM) for stress urinary incontinence
The overall aim of this project is to contribute to the health and wellbeing of nurses in order to facilitate their sustainable employability. we will develop an intervention which consists of: 1) the use of the Vitality Scan, a signal list for…
controlling diet will reduce metabolic syndrome in diabetes patients controlling metabolic syndrome will reduce the risk of coronary artery disease risk score.
It is hypothesized that the outcome of the outcome parameters will be superior for the test product compared to the control product: No difference for the test product compared to the control product is anticipated for the outcome parameter…
- We hypothesize that ingestion of BCAA will increase post-prandial plasma amino acid availability, thereby increasing myofibrillar muscle protein synthesis rates above basal values. - We hypothesize that ingestion of BCKA will increase post-…
The main objective is to evaluate the Dutch Guidelines for Healthier Canteens in daily practice in secondary schools. Therefore on process level we will explore among different stakeholders (from caterers and school) how they experience…