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We hypothesize that in many patients there will be an inconsistency between administrating medication and registration in the EHR of more than 15 minutes. Making retrospective studies drawing conclusions on data from the EHR less reliable.
Reducing the dose in the setting of therapeutic drug monitoring (TDM) does not affect clinical disease activity and safety, while it will reduce costs.
The combination of PARP and PD-L1 inhibition has a synergistic effect and will result in progression free survival improvement.
LEND surgery is a (cost)-effective treatment option for patients with Diabetes and lower extremity compression neuropathy, compared to conventional (non-surgical) care.
Chemodenervation by lidocaine of the m. vastus intermedius and the m. rectus femoris improves gait pattern in stroke patients presenting a stiff knee gait.
A switch to thrombininhibitor dabigatran or addition of tranexamic acid to the factor Xa inhibitor may be effective in women who experience heavy menstrual bleeding during anticoagulant treatment with factor Xa inhibitors.
Paravertebral analgesia is associated with superior quality of recovery by achieving comparable pain control whilst having less side-effects.
The hypothesis is that twins discordant for pregnancy complications display a distinct epigenetic signature in MSCs. This signature contributes to cellular metabolic alterations and is associated with future cardiovascular and neurodevelopmental…
Not applicable
The goal of the proposed study is to test the null hypothesis that vaccination will not boost the cytotoxic T cell responses against UTA2-1 in >20% of the patients.
Our hypothesis is that we can achieve comparable clinical outcomes with accurate virtual 3D planning and surgical preparation only.
PPI administration to women with confirmed PE lowers sFlt-1 levels and which may lead to less complications or progression of disease.
Based on recent data derived from animal research in combination with earlier clinical trials, we hypothesize that stimulation of cerebellar nuclei in pediatric refractory epilepsy patients might be effective in significantly decreasing epileptic…
To identify (both primary and acquired) resistance mechanisms to chemo-immunotherapy (obtained by less invasive procedures (NGS on ctDNA in blood & urine, exhaled breath or microbioma in stools alone or in combination)) and provide new…
Different processing of milk products will have impact on metabolic availability of amino acid
The intervention will result in: - higher observed sensitivity and more positive attitudes towards sensitive caregiving in professional caregivers - lower cortisol levels, higher wellbeing and more attachment security in infants - less separation…
Based on most recent insights in AAV treatment, the present study intends to evaluate whether combining rituximab with cyclophosphamide is superior to current standard of care with rituximab only to induce a favorable immunological state of MRA in…
Interventions to promote indicator condition-guided testing for HIV in the hospital will facilitate earlier identification of HIV infection and therefore ultimately help stop HIV
It is hypothesized that GSH CBT-E is superior to the waiting list condition with regard to a decrease in eating disorder pathology and clinical impairment. GSH CBT-E is also expected to be superior to the waiting list with regard to increase in the…
NIRF imaging during minimally invasive resection of liver metastases can aid in achieving higher radical resection rates in patients with colorectal liver metastases.