427 resultaten
N/A
The RAINBOW study: Rheumatoid Arthritis ImplemeNtation of Biological dose Optimization in real World
We hypothesize that a multifaceted implementation strategy can stimulate the use of tight control and bDMARD dose optimization in clinical practice, measured by decreased bDMARD use and non-inferiority on disease activity at 18 months.
Children participating in daily sport classes will attain higher academic achievement than their counterparts who participated in the standard physical education classes incorporated in the school curriculum (1 hour/week).
This project will deliver a user-centred evidence-based patient decision aid, supporting couples with hereditary cancer in their decision making regarding fulfilment of their child wish. The decision aid will facilitate couples with an hereditary…
We hypothesize that the active strategy leads to a better functional outcome than the conservative strategy three months after acute ischemic stroke, in patients with elevated pre-treatmen blood pressure otherwise eligible for intravenous…
1. does pseudophakia influence intra ocular pressure (IOP) lowering effect of SLT? 2. the effect of SLT relies on an inflammatory reaction. Anti-inflammatory therapy is often used immediately following SLT, does this influence the IOP lowering…
In this RCT we investigate the effects of two school-based physical activity interventions (aerobic exercises versus coordinative exercises) in primary school children on executive functions and academic achievement. We hypothesize that both aerobic…
What are the motivations of women in the Netherlands to choose UC and what are their beliefs on childbirth in general and in relation to current Dutch maternity care? This study primarily aims at understanding women’s motivations in declining (parts…
•To assess the safety and tolerability of induction doses of ABP-700 and determine dosing regimens that reliably produce drug induced unconsciousness and the pharmacodynamic conditions necessary for induction of general anesthesia with ABP-700 alone…
1. Gatekeeper training is effective in enhancing relevant skills 2. Gatekeeper training will diminish rates of (attempted) suicides at regional level 3. The intervention is cost-effective relative to routine medical care
Surgical procedures are accompanied by high levels of distress and pain in the adult as well as the pediatric population. Music interventions have shown to reduce this anxiety and pain in adult populations. In this study, we will investigate the…
At equi-analgesia respiratory depression from oxycodone is manifold greater compared to Tapentadol
Is there a diiference in antidepressant efficacy between ECT and a combination of ECT and nortriptyline? Does combination therapy with ECT and nortriptyline result in a faster antidepressant response compared with ECT monotherapy? Does combination…
The rationale for this study is to assess the visibility and positional accuracy of the laser marks. Combined with VLE imagery, the targeting enabled by the laser marking system could have the potential to increase the diagnostic accuracy of current…
We hypothesize that SNNS might be of great value in early esophageal cancer, especially in the treatment of high-risk early EAC (T1b-tumors). A treatment algorithm consisting of endoscopic resection of the tumor, followed by SNNS and (adjusted) LN…
In this randomized, single blinded controlled trial, we evaluate the role of ketamine as an analgesic component of procedural sedation. We compare the effects of propofol-ketamine versus propofol-alfentanil and propofol-remifentanil for achieving a…
Differences in the healthcare, workplace, legislative, and personal systems (see figure) as well as evaluator and patient characteristics may better explain differences in FCE results
We hypothesise that accurate treatment of GOLD D patients in an integrated primary care system will improve patient outcomes over 12 months.
The aim of the pilot trial is to: 1. evaluate the potential effectiveness and effect size of the online self-management program for patients with Cardiovascular Risk 2. to identify outcome measures most likely to capture potential patient benefit…