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We aim to test the accuracy of Western gastroenterologists in differentiating T1 CRCs from its precursor lesions and subsequently in estimating invasion depth
A safe RP2D of Vyxeos®/CPX-351 in combination with clofarabine can be identified in this phase 1b study.
Benign liver tumors and cysts carry a significant burden on the quality of life in some cases. Apart from impairing symptoms, psychological burden might provide sufficient ground for surgical intervention. There is a variable approach to them…
We hypothesize that in critically ill patients, measuring the anti-factor-Xa randomly in a 3 to 5 hours timeframe, may introduce a significant variation in the measured anti-factor-Xa and can seriously underestimate the real peak anti-factor-Xa.
Trifluridine is primarily metabolized through degradation by thymidine phosphorylase to the inactive metabolite 5-(trifluoromethyl)-uracil (FTY) without any involvement of the cytochrome P450 enzyme system. The primary route of excretion of…
Exploratory study investigating the efficacy of the currently recommended dosing regimen of ciprofloxacin prophylaxis in patients treated for haematological malignancies.
Fiducial markers placed on endoscopically determined tumor borders are a good surrogate for macroscopic tumor.
We hypothesize that dietary supplementation with seaweed will improve glucose regulation in T2DM patients.
It is an observational study, no null hypothesis has been formulated. The purpose of StEM is to understand the expectations, needs, experiences, choices and decisions of pregnant women and women who recently gave birth in the Netherlands, recording…
High-resolution ultrasound (HRUS) is a quick and cost-effective technique to study the morphology of peripheral nerves. Sonographic characteristics of plexiform neurofibromas and MPNST have been described in the literature. Recently, a pilot study…
To determine the influence of the fatty beverage Cow’s milk on the systemic exposure (AUC) to erlotinib in patients with or without concomitant use of a PPI.
Main question: Is Theraplay an effective treatment method for children with ASD and what is the effect of treatment with Theraplay on their parents? Prior RCTs proved that Theraplay leads, among other things, to a decrease in internalizing problem…
Awake craniotomy improves safety and efficacy during surgery for glioblastoma in eloquent areas
1) Molecular analysis of breath can be used to discriminate between patients that are suspected of ventilator-associated pneumonia (VAP) who have positive cultures and who have negative cultures with high sensitivity (which could limit antibiotic…
Individual-directed resilience training can reduce chronic stress and prevent burnout among students
The use of motivational counselling and inclusion of a written health plan in an occupational health examination will improve personal work resources and work ability at 12 months follow-up
Treatment of fear of falling in hip fracture patients in GR, using the FIT-HIP intervention, will lead to reduction of fear of falling and therefore to an improvement of mobility function (gait and balance), in comparison to patients with fear of…
Fecal Immunochemical Testing as a Tool to Determine the Need for Colonoscopy in Symptomatic Patients
Using two FIT tests in symptomatic patients prior to colonoscopy can be a useful preselection tool to determine the need for colonoscopy in symptomatic patients.
1. To assess the safety and tolerability of different doses of a single IV injection of OTL-038 2. To assess the efficacy of ascending doses of a single IV injection of OTL-038 in detecting ovarian, renal cell or endometrial cancer during surgery by…
Reducing the dose in the setting of therapeutic drug monitoring (TDM) does not affect clinical disease activity and safety, while it will reduce costs.