85 resultaten
After absorption tamoxifen is metabolized by CYP3A4 and CYP2D6 in several (active) metabolites of which endoxifen is the most important.(11) Tamoxifen, like many anti-cancer drugs, relies on phase II metabolism before they can be excreted from the…
This is an exploratory pilot study without specific hypotheses.
This study aims to apply state-of-the-art immune tests quantifying the immunosuppressive state in individuals, and the relationship between these pharmacodynamic tests and the pharmacokinetic profile (in whole blood and intracellular) after a single…
The primary objective of the study is to investigate whether an induced nocebo effect can be effectively reduced by open-label counterconditioning, combined with open-label verbal suggestions, as compared to continued nocebo conditioning and…
1) The checklist 'Attune & Stimulate' is a valid instrument to assess the arousal level of clients with SID. 2) Caregivers who are randomized to the intervention group that is instructed to use the A&S-checklist attune…
The Handscan is supposed to be more accurate than the current widely used DAS 28, it might be able to measure subclinical disease activity. We want to investigate in which clinical situation, the handscan can be an aide in decision making or can be…
Endoscopists that received an online training module (December 2017) will increase their proximal serrated polyp detectionrate
1. We hypothesize that well-trained strength athletes (using AAS) will have significantly greater organ volume when compared to well-trained strength athletes (not using AAS) and recreationally active participants (not using AAS). 2. We hypothesize…
Adding Paracetamol to treatment with Remifentanil/ Patient Controlled Analgesia for management of labour pain ("multimodal pain management") reduces opioid (Remifentanil) consumption
H1: The two versions of PAUL are perceived at least moderately useful in user friendliness, attractiveness, satisfaction and usefulness; H2: Individuals who use Smart PAUL are more engaged with the app than individuals who use Basic PAUL; H4:…
No formal statistical hypothesis is planned
Health outcome indicators of parents and children in Northern Wijchen have improved in the period 2017-2019.
The hypothesis of this study is that treatment and diagnosis of challenging behavioural symptoms, (which are or have been reason for off-label psychotropic drug prescription), as provided by this integrative team, when optimising the use of off-…
The growth-mindset intervention will result in more resilient and motivated learners and better school performance than the control intervention.
Both interventions (GRAIL training & endurance and strength training (control intervention)) will result in an increase in gait speed, functional walking ability and social participation. However, the GRAIL training will result in larger…
Inguinal hernia application provides real-time monitoring. It also might provide more accurate, more reliable and more extensive data on recovery after surgery. Patients are questioned in a less intrusive way, leading to more compliance en less…
It is hypothesised that optimizing visualization of the muscle boundries wil improve quantitative muscle ultrasound, which should increase the correlation between the outcome of quantitative muscle ultrasound and magnetic resonance imaging.
We hypothesize that protein hydrolysate supplementation will attenuate the loss in muscle mass during 7 days of immobilisation and will augment the rate of muscle mass re-gain during recovery.
The hypothesis of this study is that PROMs have a significant meaning in the management of patients undergoing inguinal hernia repair.
Combining digital FDG-PET/CT and DW-MRI imaging will more accurately predict and define response in rectal cancer patients after neoadjuvant treatment.