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Musculoskeletal complaints in patient with congenital disorders of the hand and arm.

Patients with a congenital anomaly are more likely to develop musculoskeletal complaints compared to healthy individuals.

What matters most to patients in the acute care

One of the priorities for improving the quality of care is to make care more patient centred. Current acute medical practice focuses strongly on the medical diagnosis and treatment of the medical condition. Many of the conversations in these…

FLAMSA chemotherapy directly followed by donor stem cell transplantation in elderly patients with acute myeloid leukemia (AML) or high risk myelodysplasia (MDS)

In this study we explore the feasibility of the sequential use of FLAMSA chemotherapy and T cell depleted reduced intensity conditioning allogeneic stem cell transplantation followed by donor lymphocyte infusion at 3 and 6 months after…

The effect of flavonoids and vitamin C on periodontitis

1. The use of food supplements containing vitamin C with quercetin and other flavonoids can reduce inflammation clinically (assessed by means of periodontal parameters), and systemically (assessed by means of biomarkers), in patients diagnosed with…

Modifying psychologicAl Treatment to the CHaracteristics and needs of cancer survivors.

- Personalized psychological care is more efficacious than standard, non-personalized psychological treatment in improving functioning of cancer survivors. - Personalized psychological treatment is more efficacious than standard, non-personalized…

Valco studie

Objective: To assess the diuretic effect of three standard glasses of beer, red wine and spirits in euhydrated elderly men.

Intermittent Self-catheterization: Predictors of Succes

This trial aimes to identify patient characteristics which can lead to predictors of succes for technique learning.

SUPplementary REgional anesthesia in MAmma surgery (SUPREMA trial).

The incidence of postoperative nausea and vomiting (PONV) varies from 20 to 80% in patients undergoing mamma surgery. PONV are strongly related to postoperative pain. PONV are also well known side effects of opioids. Appropriate pain management…

Early education on renal replacement therapy to kidney patients in the pre treatment phase and their social network: A
home based approach.

1. Participation in an early home-based education programme compared to care as usual will significantly increase knowledge on kidney disease and treatment options, communication on renal replacement options and promote a positive attitude towards…

Vaststellen van ziekteverwekkers van griepachtige verschijnselen bij ouderen.

Influenza-like-illness (ILI) is not only caused by an influenza virus infection, but also by other pathogens, both viral and bacterial. In this study nose and throat swab samples will be taken during ILI episodes to identify pathogens causing ILI in…

Testing the effectiveness of rookexperts.nl: an intervention for increasing intention to quit among hardcore smokers based on motivational interviewing.

Hard-core smokers are smokers who have been smoking for many years and who do not intend to quit. This makes them vulnerable to disease and death. Since hard-core smokers are unlikely to quit smoking, before aiming at actually quitting, we first…

Reducing antiepileptic medication during a multiple-day video-EEG to investigate the feasibility of epilepsy surgery: what is the best way (safest and most efficious) to reduce antiepileptic drugs?

Combining factors will enable prediction of successful long-term video-EEG monitoring and of adverse effects, related to antiepileptic drug withdrawal.

Galileo trial

The use of a GDFT protocol during liver surgery instead of the widely used LCVP regimen has no influence on blood loss.

“Tissue damage due to harvesting of the Great Saphenous Vein (GSV) for femoropopliteal bypass surgery”

To use the GSV for bypass surgery it is of the utmost importance to subtract the vein with as limited damage as possible. To harvest the GSV three techniques are generally used, namely; Standard reversed technique using additional incisions in the…

Potential effect of proton-pump inhibitor on angiogenic markers in preeclampsia

PPI administration to women with confirmed PE lowers sFlt-1 levels and which may lead to less complications or progression of disease.

Comparison of heart minute volume measured with the standard method (pulmonalis catheter) with a new method using the arterial wave form in groin or at the wrist in serious sick patients in the intensive care.

The aim of the study is to determine whether cardiac output measurements obtained using APCO are comparable with those obtained using intermitted thermodilution cardiac output in critical ill patients.

Implementation and evaluation of shared decision-making for breast cancer follow-up care

Successful implementation of a patient decision aid regarding breast cancer follow-up care facilitates shared decision-making and results in quality improvement in breast cancer follow-up care.

The effect of the acid-reducing drug esomeprazol on afatinib in lung cancer patients

Acid-reducing drugs, such as PPIs, may profoundly decrease solubility and, as a result, (negatively) affect the bioavailability of afatinib. Since a PPI is often used concomitantly during afatinib therapy, this DDI confronts physicians, patients,…

Monotoring capacity and performance of stroke patients using instrumented clothing

1) It is possible to record data delivering insights in the actual performance of activities of daily life using the Interaction system in stroke patients in the home environment. 2) It is expected that standard clinical test scores do not…

Treatment of functional neurological symptoms.

The primary aim of this study is to investigate whether patients with neurological functional somatic symptoms have less limitations in daily activities 12 months after short-term educational treatment by neurologists, when compared to the current…