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Comparison of progression free survival (PFS) in elderly patients with advanced CRC treated first line by tegafur-uracil plus LV or capecitabine. It is considered that, in this patient population, only differences in the median time to progression…
Tacrolimus (FK506) is the main immunosuppressant that is prescribed after kidney transplantation. One of the disadvantages of Tacrolimus is the small therapeutic window. In transplantation patients therapeutic drug monitoring is routinely performed…
Simvastatin (an HMG-CoA reductase inhibitor) induces apoptosis in vitro and sensitizes the myeloma cell to chemotherapy. This is the first clinical trial to test if in vivo there is the same sensitization in relapse or refractory multiple myeloma.
Based on literature we assume a 20% day 30 mortality of patients admitted to the hospital ward with COVID-19. We aim to lower this day 30 mortality to 10%.
Is there a diiference in antidepressant efficacy between ECT and a combination of ECT and nortriptyline? Does combination therapy with ECT and nortriptyline result in a faster antidepressant response compared with ECT monotherapy? Does combination…
The procoagulant state seen in patients with hiv can be a result of the immune activation due to the hiv infection itself or combination antiretroviral therapy (cART). In case the acquired thrombophilia is a result of immune activation, the…
we hypothesize that thermal comfort and sensation will stay within similar ranges in both conditions (based on a previous study);
Based on current literature we hypothesize that mindfulness based stress reduction training reduces psychological distress and improves 'positive mental health' in medical interns. Possibly MBSR can prevent psychological distress in the…
Inhalation of rhDNase before sleep increases the expiratory flow at 25% of the actual forced vital capacity (MEF25) compared to inhalation of rhDNase in the morning.
Patients who are in 1st CR after autologous transplantation, may be randomized between no further treatment (arm A) and maintenance chemotherapy (arm B). The hypothesis to be tested is that maintenance therapy will prolong disease free survival,…
We will investigate the effects of high dairy intake on metabolic flexibility, glucose metabolism and insulin sensitivity, which are all important characteristics of (metabolic) health. We hypothesize that high dairy intake improves insulin…
rapid assessment by an Emergency Physician supported by priority lab testing (PLT) will reduce length of stay in the emergency department
Intrathecal methylprednisolone reduce the features of central sensitization in patients with complex regional pain syndrome type 1 having symptoms longer than 6 months and shorter than 6 years.
A more gradual training program for novice runners, will result in a reduction of running related injuries in novice runners.
MMR vaccine administered intramuscularly induces the same adverse effects and immunogenicity as subcutaneously.
Early provision of AFOs (± 2 wks after stroke) is expected to positively affect walking impairments, mobility and activities of daily living after acute stroke compared to providing AFOs later on in the rehabilitation process (± 10 wks after stroke…
1) In what proportion of severe hypoxic COVID-19 patients on HFNC is invasive mechanical ventilation necessary? 2) In what proportion of severe hypoxic COVID-19 patients with an DNI code on HFNC results in progressive respiratory failure or death?
Does lipid accumulation in skeletal muscle and the heart effect mitochondrial function in relation to insulin resistance?
Treatment with Infliximab will reduce loss of visual acuity by 8 letters or better on the ETDRS chart.
The intention to change behavior is related to changes in multiple physiological variables. Thermal comfort and thermal sensation are related to these physiological parameters. Furthermore, the intention of behavior is related to changes in thermal…