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Minimally Invasive versus Classical Procedures for Posterolateral and Anterolateral Approaches in Total Hip Arthroplasty. A randomized, double-blinded trial.

As the anterolateral approach is also a routine procedure, and to test how minimally invasive MIS is, we hypothesized that patients treated with a THA using a posterolateral or anterolateral MIS would experience superior clinical results compared…

Exploration of implicit biases in adults who are current cocaine users

1. A decrease in cocaine use over a three month period in participants who receive AAT training as opposed to VPT training. 2. A change in symptoms involving craving, the urge to use, withdrawals well as stated readiness to change in participants…

Study on the possible pharmacokinetic interaction between green tea supplements and tamoxifen in patients with breast cancer. “the TEA study”

After absorption tamoxifen is metabolized by CYP3A4 and CYP2D6 in several (active) metabolites of which endoxifen is the most important.(11) Tamoxifen, like many anti-cancer drugs, relies on phase II metabolism before they can be excreted from the…

Folic acid and carotid intima-media thickness: a 3-year RCT examining the effects of folic acid supplementation on vascular disease.

N/A

A randomized phase II multicenter study with a safety run-in to assess the tolerability and efficacy of the addition of oral tosedostat to standard induction therapy in AML and RAEB ≥ 66 years and very poor risk AML ≥ 18 years.

To assess the tolerability and efficacy of the addition of oral tosedostat to standard induction therapy.

Decision for reconstructive interventions of the upper extremities in tetraplegia: the effect of treatment characteristics.

None; study was a survey.

Quantify the ability of the human hand to perform independent movements

The main objective of this study is to determine the rate people convey information through their hand. The secondary objective is to assess the mental workload of the subjects through a questionnaire. Moreover, as we already have pilot data from…

A randomized, multicentre, open label trial comparing the start of the induction of labor with intravenous oxytocin according to the circadian rhythm with standard care.

Our hypothese is that induction of labor with intravenous oxytocin starting in the evening, following the circadian rhythm, shortens the duration of labor compared to a start in the early morning.

Het ontwikkelen van een predictiemodel voor de transitie van acute pijn naar pijn die meer dan 3 maanden persisteert

We hypothesize (based on literature) that the incidence of chronic pain in The Netherlands is around 15-20% in patients presenting to the emergency department with (acute) pain related complaints. We have no further hypothesis, because of the…

DELPHI-trial and DELPHI-SPECT.

Dose-escalation of paroxetine (up to 50 mg/day) does not increase efficacy of treatment of Major Depressive Disorder in patients who did not respond to a 6 week trial of paroxetine in a standard dose (20 mg/day).

MAPLE A
(Melatonin Against PLacebo in Elderly patients).

Hypothesis is that elderly patients, acutely admitted for hip fracture, treated with melatonin for 5 days will experience less delirium than patients treated with placebo.

Breakfast replacement by a low-glycemic index liquid formula in patients with diabetes mellitus type 2.

N/A

Clinical differences between atopic and atopiform dermatitis.

We hypothesize that atopiform dermatitis is a separate entity with specific characteristics, which needs recognition in order to be diagnosed and treated appropriately.

In-vivo validiation of a non-invasive, magnetic resonance-based patient-specific pressure model to determine the severity of common and external iliac artery obstructions, and the need for revascularization.

The one-dimensional personalized pressure model is able to predict the pressure drop over stenotic lessions in the common and external iliac arteries.

The effect of Marinol (tetra-9-hydrocannabinol) on the frequency of TLESRs.

Cannabinoid receptor (CB1) agonists, like marinol, lower the rate of TLESRs and can be useful in the treatment of gastroesophageal reflux disease (GERD).

Prevention of catheter-related deep vein thrombosis with nadroparin in hemato-oncology patients treated with high dose chemotherapy.

Low dose nadroparin will prevent symptomatic and asymptomatic catheter-related deep vein thrombosis in patienten treated with high dose chemotherapy.

Vitamin B6 study

Supplementation with pyridoxine-5'-phosphate will not lead to an increase in plasma concentrations of pyridoxine

Amsterdam Wrist Rules (AWR).

Patients with a wrist trauma represent a substantial part of the patient population at the Emergency Department. Most hospitals routinely carry out a radiological examination of patients following wrist trauma to exclude a distal radius fracture.…

Elucidating the therapeutic mechanism of DBS

This is an exploratory pilot study without specific hypotheses.

The project ‘Don’t forget the mouth!’

The project DFTM! could be implemented as planned, and contributes positively to the oral health