Zoeken naar een onderzoek

RESolutie van Ontsteking in de Luchtwegen na Virale Expositie.

We hypothesize that allergic asthmatics are less capable in resolving inflammatory cells after viral airway infection as a consequences of impaired expression of indoleamine 2,3-dioxygenase.

Randomized study of Early Assessment by CT scanning in Trauma patients.

A trauma care strategy involving early shockroom CT scanning with a standard diagnostic imaging strategy in trauma patients has a positive effect on both patient outcome and operations research.

Evaluation of Vascular care in Alzheimer's disease.

Intensive vascular care, aimed at secundary prevention of cerebrovascular disease, is efficacious in patients with Alzheimer's disease that have vascular lesions on MRI.

BeSt Treatment Strategies. A randomized clinical trial to test the effectiveness of different treatment-strategies in patients with early rheumatoid arthritis. Long term follow-up.

1. Earlier identified differences in functional ability and radiological damage progression are maintained in the next ten years; 2. Early suppression of disease activity results in long term improvement in functional ability and suppression of…

Cost-effectiveness of transvaginal hydrolaparoscopy in the work-up for subfertility.

To diagnose tubal pathology various diagnostic tests are available. The current first line diagnostic test for tubal patency testing is hysterosalpingography (HSG). Transvaginal hydrolaparoscopy (THL) has recently been developed as a new outpatient…

HORSE trial

The correlation between alcohol intake and dehydration is observed in several studies. ORS, Oral Rehydration Solution is a reliable treatment for dehydration. The link between ORS and relieve of veisalgia has been suggested by several sources,…

Protein and lifestyle intervention to preserve muscle mass in obese older type 2 diabetes patients – a 13-week randomised, controlled exploratory study with a 24-week follow-up period.

H0: The effect of using test intervention is equal to the effect of the control intervention with respect to change in leg muscle mass in obese older adult patients with type 2 Diabetes after 13 weeks of intervention H1: The effect of using test…

Does Aprepitant (Emend ®) influence fentanyl PK?

Fentanyl is a strong opioïd and is highly lipophilic. Fentanyl pharmacokinetics are characterised by large inter- and intrapatient differences, which may have serious consequences for the activity and toxicity profile of this drug. The use of…

BasIQ-4® a new approach towards performing episiotomy

to further evaluate and monitor the safety and performance of the “BasIQ-4®” in a population of women delivering in general hospitals in The Netherlands when used as intended

Optimizing primary vaccination schedule for premature infants

To determine immunogenicity of NIP vaccines in preterm infants when vaccinated according to the current Dutch NIP schedule and with rotavirus vaccine following the RIVAR study. To unravel the mechanism of immature host responses and interaction with…

Protocol for treatment and research of acute lymphoblastic leukaemia of childhood
of the Dutch Childhood Oncology Group (SNWLK/DCOG ALL-9).

This reduced intensity protocol is instituted to: 1. Confirm the data obtained in the SNWLK-ALL-6 protocol for standard risk patients; 2. Offer significant improvement of cure rate in high risk patients, comparable to international childhood ALL…

NGAL an early biomarker for acute kidney injury

NGAL is an early predictive biomarker for acute kidney injury in a heterogeneous adult ICU population.

Growth and development of children born after IVF.

Conditions during an IVF procedure might interfere with fetal growth and development and thereby permanently influencing the programming of organs and their function.

Stop or Go? Relapse prevention training with guided tapering of antidepressants during pregnancy. A pragmatic multicenter RCT to investigate risk and benefits for mother and child.

1) Tapering of SSRIs with added preventive cognitive therapy (CT) increases the risk of clinically relevant maternal relapse of depression in excess of [absolute] 15% compared to continuation of SSRIs. If rejected, then discontinuation is deemed non…

Dopamine on top of standard treatment for patients with exacerbation of Heart Failure, at home situation.

This study will investigate whether 24 hour dopamine infusion reduces the need of hospital admission for patients with exacerbation heart failure.

"The Medical Emergency Team (MET):
Hospital Outcomes after a Day" study

Patients subject to MET review have a high in-hospital mortality (20%). Thus, understanding the outcome of patients within the first 24hr of MET review is important in developing quality improvement and interventional studies to reduce this…

The psychological well-being and health-related quality of life of patients admitted to the hospital with COVID-19.

We hypothesized that patients admitted to the hospital during this pandemic period with a suspected or confirmed SARS-CoV2 infection, have a high risk to develop long-term or persistent symptoms of PTSD, anxiety and depression, which are associated…

PRESERVE TRIAL:
Pancreatic beta-cell dysfunction REStorEd by Rosiglitazone and Valsartan Effects. A 52-week randomized controlled factorial study in subjects with IFG and/or IGT.

Amendment 2007: PancREatic beta-cell dySfunction rEstoRed by Valsartan Effects – PRESERVE Study.

Amendment 2007: In stead of two medicaments (Rosiglitazon and valsartan), only valsartan has been completed. Due to negative publicity, Rosiglitazon was stopped. Target number of participant is thereby decreased from 144

Type 2 diabetes is cause by progressive beta-cell dysfunction against a background of obesity and insulin resistance in susceptible individuals. Peroxisome proliferator-activated receptor (PPAR) gamma-mediated mechanisms are involved in the…

The efficacy of cognitive behavior therapy and aerobic exercise training for decreasing experienced fatigue in patients with facioscapulohumeral dystrophy.

Aerobic exercise therapy (AET) and cognitive behavioral therapy (CBT) are hypothesized to be both more effective in improving activity level and, with that, decreasing experienced fatigue of FSHD patients compared to the usual care. The maintenance…

Screening for risk of posttraumatic stress disorder in children and parents after an accident.

Develop a screening tool to identify children at risk of posttraumatic stress disorder after an accident.