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A phase II study of clofarabine in combination with cytarabine and daunoxome for children with acute myeloid leukemia withour other treatment options.

This is a dose-escalation study to determine the safe dose of clofarabine given in combination with cytarabine and liposomal daunorubicin.

Effect of a fibre-enriched versus standard pediatric tube feed on the intestinal flora, gastrointestinal function and nutritional status of 7-12 year old children.

Improvement of the intestinal microflora of children consuming a fibre-enriched versus a standard paediatric tube feed.

Effectiveness of a participatory approach on the use of four ergonomic measures reducing musculoskeletal disorders among construction workers compared with no intervention.

It has been hypothesised that, because participatory ergonomics (PE) implementation strategies intervene at all phases of behavioural change for the various stakeholders, they may be successful in increasing the use of ergonomic measures at…

Demineralized bone matrix (DBM) as an alternative for autogenous bone graft in high tibial valgus opening wedge osteotomy (HTO) for symptomatic medial compartmental knee osteoarthritis.

Opening wedge HTO treated with DBM will better match one year post-operative mechanical axis alignement with pre-operative planned correction then opening wedeg HTO filled with autogenous iliac crest bone.

LABELLO II: Single shots and ropivacaine levels.

Is there some course detectable in the ropivacaine levels in the collected shed blood in patients treated with three single local analgesia shots with ropivacaine after total knee replacement.

Effects of exercise training on O2 onset and recovery kinetics at submaximal exercise in patients with chronic heart failure.

The time constant of oxygen uptake during recovery of submaximal exercise is a reliable parameter to measure effects of exercise training in patients with chronic heart failure.

A safety and growth study with a new fat blend.

Based on the human milk composition, Nutricia Research has developed a new infant formula with a new fat blend, more similar to that of human milk. This new formula is currently being studied for safety and its effects on growth. The comparator used…

Catheter ablation versus Amiodarone to pRevent Future ventricular tachycardia Episodes in patients with a defibrillator and a history of a myocardial infarction.

Time to recurrence of sustained VT (longer that 30 seconds or with hemodynamic instability) or VF with or without documented ICD therapy (shock or ATP) for VT of VF will be longer in patients randomized to substrate based ablation than in patients…

A relapse prevention study for anxiety patients who want to discontinue antidepressant medication.

The hypothesis is that offering CBT in a group format while discontinuing antidepressant medication will reduce the high relapse rates in remitted anxiety disorder patients who discontinue pharmacological treatment.

PIPAC for peritoneal metastases of colorectal cancer

Repetitive ePIPAC-OX as a palliative monotherapy is a feasible, safe, tolerable, and potentially effective treatment for isolated unresectable colorectal peritioneal metastases, with low and predictable costs and a low systemic uptake of oxaliplatin…

Efficacy of Inhaled RhDNase in Mechanically Ventilated Pediatric Patients with an Atelectasis.

RhDNase can liquefy mucus in children with an atelectasis during mechanical ventilation, resulting in improved mucociliary clearance, less mucus retention and less airways obstruction, thereby enhancing the rate of resolution of an atelectasis.…

Prevention of Depression and Anxiety in Adolescents with a High Familial Risk.

The effectiveness of an indicated indicated depression and anxiety prevention program ('Een Sprong Vooruit') will be tested in a Dutch sample of adolescents (aged 11-15) with high familial risk. It is expected that the adolescents who…

Information processing, neuropsychological, and neurobiological processes in pediatric obsessive-compulsive disorder.

Information-processing: 1. Changes in measures of severity of OCD are explained (partially) by changes in measures of meta-cognitions (explicit and/or implicit); 2. Changes in measures of meta-cognitions (explicit and implicit) precede changes in…

Thuis in de opvang: Een fijne start voor baby’s

The intervention will result in: - higher observed sensitivity and more positive attitudes towards sensitive caregiving in professional caregivers - lower cortisol levels, higher wellbeing and more attachment security in infants - less separation…

A Randomized Trial comparing Surveillance with Radio-Frequency Ablation of Barrett’s Esophagus with Low-Grade Dysplasia; the SURF-study.

Radiofrequency ablation (RFA) will lead to permanent and complete eradication of Barrett's epithelium. This will prevent development of high grade intraepithelial neoplasia (HGIN) or early carcinoma and may eliminate the need for endoscopic…

SUstainable PREvention of cardioMEtabolic risk through NUDGing hEalth behaviors

Changing the context in which individuals make lifestyle choices has a sustained impact on the dietary intake and cardiometabolic health.

Introduction and effects of structured drug counselling in the hospital.

The intervention lead to: 1. More knowledge about (the use of) prescribed medicines; 2. A better use of medicines during the stay in the hospital and after discharge.

An exploratory study to evaluate the effect of a new study product on early programming in healthy infants.

The investigational formula will be equivalent to the control formula with regard to the postprandial blood lipid parameters.

Transcranial magnetic stimulation to the right parietal cortex in the treatment of depression.

Ten consecutive sessions of 2 Hz TMS (inter-pulse interval: 1 sec) at 90% MT to the right parietal cortex (2400 pulses p/session) will have antidepressant effects.

Does a preoperative subconjunctival injection of Dexamethason reduce the incidence of proliferative vitreoretinopathy in patients with ablatio retinae?

A preoperative subconjunctival injection of Dexamethason reduces the incidence of proliferative vitreoretinopathy in patients with ablatio retinae.