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Aerobic Muscle Capacity in PPS.

Research questions and accompanying hypotheses: 1. Is there a difference in fatigue resistance of the knee extensor muscles between patients with PPS and able-bodied control subjects and is this related to aerobic capacity? Hypothesis: It is…

Evaluation of the mucosa-permeability of the stomach measured by the Ussing Chambers technique in patients with functional dyspepsia before and after treatment with amitriptyline.

Through stress the mast cells become activated and by their vaso-active substances the mucosa permeability will become increased. Therefore the mucosa is easier to penetrated by microbes and acid. This increased permeability will leads to…

The influence of psychological factors on the onset and course of Complex Regional Pain Syndrome Type I.

Psychological factors (e.g. personality style) influence the course of CRPS-I but not the onset of this syndrome.

IMPROVED: Induction therapy with Methotrexate and Prednisone in Rheumatoid Or Very Early arthritic Disease.

There is a clinically and statistically significant difference in the percentage of patients who achieve and maintain clinical remission (defined as DAS < 1.6) and in functional ability and progression of radiological joint damage after 1…

Rustmetabolisme in kinderen met kanker

REE zal gemeten worden middels indirecte calorimetrie. Zuurstofverbruik (VO2) en koolstofdioxide productie (VCO2) worden gemeten. De respiratoire quotient (RQ) zal verkregen worden uit de VO2 e n VCO2.  Lichaamssamenstelling zal…

Effect of Computer-Controlled Cooling on Surgical Aspects after a Displaced Intra-Articular Calcaneal Fracture (Cool-DIACF); A Multicenter Randomized Controlled Trial

We expect that preoperative and postoperative cooling will reduce swelling faster, reducing the time to surgery and time to discharge, respectively.

Urological complications after live donor kidney transplantation: Intravesical or extravesical ureterovesical anastomosis?

Our hypothesis is that the extravesical technique reduces the incidence of PCN placement, and urological complications.

Haemolysis during extracorporeal CO2 removal; a laboratory study using donated human blood.

Objective: to investigate in vitro a relationship between plasma free haemoglobin and extracorporeal life support-related parameters such as pump flow, catheter selection, pump speed and pump heating. 1. Blood flow is positively related to plasma…

Intra uterine pressure monitoring for augmentation or induction of labour with intravenous oxytocin: Benefits and costs.

Our hypothesis is that use of an IUPC, during augmentation or induction of labour with intravenous oxytocin, will reduce the number of instrumental deliveries from 25% to 16%.

Clonidine als toevoeging voor de verlenging van pijnbestrijding bij oogoperaties.

Clonidine as an adjuvant in retrobulbar block reduces post-operative pain and use of analgesics.

Use of preoperative desmopressin in preventing bleeding in patients treated with SSRI's.

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Biochemical efficacy and tolerability of allopurinol, benzbromarone and probenecid in gout.

1. Allopurinol has a poor efficacy and tolerability profile to lower serum urate to target levels <0.30 mmol/l. 2. Benzbromarone is more potent and is better tolerated than probenecid to lower serum urate to target levels <0.30 mmol/l.

The effect of a computer tailored intervention aimed at recuding alcohol consumption in heavy drinkers.

Taking part in a computertailored intervention reduces alcohol consumption more in heavy drinking men, than reading a general leaflet on alcohol.

Recurrence and Survival after laparoscopy versus laparotomy in early-stage endometrial cancer: Follow-up five years after a randomised trial

Total laparoscopic hysterectomy is equally safe with respect to five-years disease-free survival outcomes in comparison to a total abdominal hysterectomy

Diagnosing small lesions in the colon using the WavSTAT device.

The current study evaluates whether accurate optical diagnosis of small colorectal polyps (<10mm) can be achieved using both the endoscopic image as well as an optical device called the WavSTAT. Accurate optical diagnose could result in the…

Voortzetting Follow-Up Imaging Onderzoek bij Glaucoom en Oculaire Hypertensie.

Structural imaging is more sensitive to early (progression) detection than functional measurements (i.e. visual fields).

Protection of colorectal anastomoses with a biodegradable device: The C-SEAL feasibility study.

Protection with a biodegradable sheath will reduce the number of anastomotic leakage.

Silencing inflammatory activity by injecting Nanocort in patients at risk for atherosclerotic disease.

Nanocort reduces vascular inflammation in patients at risk for atherosclerotic events.

A prospective double-blind multi-centre trial: Laparoscopic versus open elective sigmoid resection in patients with symptomatic diverticulitis (Sigma-trial).

That the laparoscopic approach should be preferred over the open procedure in cases of an elective sigmoid resection for symptomatic diverticulitis.

Optimizing ultrasound images for quantitative analysis in patients with fatty infiltration in rotator cuff tears

It is hypothesised that optimizing visualization of the muscle boundries wil improve quantitative muscle ultrasound, which should increase the correlation between the outcome of quantitative muscle ultrasound and magnetic resonance imaging.