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'Parents to be' The effectiveness of systematic population-based preconception advice and counselling initiated by GP's.

At least 20% of the pregnancies in the Netherlands end in an adverse pregnancy outcome (spontaneous abortion, preterm birth, low birth weight, perinatal death, congenital anomaly). Information on risk factors before pregnancy together with…

Impact of black tea on forearm endothelial function
De invloed van zwarte thee op de vaatfunctie

We hypothesize that black tea ingestion (approximately 530 mg tea polyphenols) in healthy middle-aged humans will lead to a larger mean forearm blood flow response to acetylcholine (i.e. endothelium-dependent vasodilation) We hypothesize that black…

A preoperative diet to increase resistance of patients undergoing surgery.

Multiple studies have shown that dietary restriction extends lifespan in different animal species ranging from worms to rats. The beneficial effect of calorie restriction on life span may function in part through its ability to increase stress…

Embryo selection by metabolomic profiling.

Ho: the life birth rate in patients after SET with only morphological embryo selection is equal to patients with metabolomic profiling added to morphological selection. H1: the life birth rate in patients after SET with only morphological embryo…

The effect of application of 0.12% chlorhexidine gel-toothpaste compared to 0.12% chlorhexidine mouthwash and regular toothpaste in a 3 day non-brushing model on plaque accumulation.

Tray application of 0.12% chlorhexidine gel-toothpaste has more than 15% better effect on ¡®de novo¡¯ plaque accumulation compared to tray application of regular toothpaste in a 3 day non-brushing model.

Reduce the inappropriate use of urinary catheters and intravenous (IV) catheters

Urinary and (peripheral and central) intravenous catheters are widely used in hospitalized patients, although some serious complications can occur with the use of these catheters. Up to 56% of the catheters do not have an appropriate indication. The…

Biomarker evaluation of different types of Internet-based interactive computer-tailored nutrition education on fat consumption.

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A phase I/II, double blind, cross-over design, placebo controlled, pilot study to assess the effect and tolerability of multiple oral doses of phytosphingosine in Sjögren’s patients.

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A double-blind, randomized, double dummy, cross over, study
to assess the difference in efficacy between nebulisation of rhDNase before airway clearande therapy (ACT)versus nebulisation after ACT.

Inhalation of rhDNase after airway clearande therapy (ACT) increases the expiratory flow at 25% of the actual forced vital capacity (MEF25) compared to inhalation of rhDNase before ACT.

PACES: Physical exercise during Adjuvant Chemotherapy Effectiveness Study.

The primary research hypotheses are: 1. Patients who follow the Onco-Move program will achieve better physical fitness levels, as assessed by objective performance tests, and will report less fatigue than patients in the usual care control group; 2…

Painrehabilitation: More is Better?

Pain Rehabilitation Programs (PRP’s) are proven effective for patients with chronic musculoskeletal pain (CMP). Evidence about the relationship of dose on the effect of PRP however, is unavailable. We hypothesized that shortening PRP will not be…

Study on chronic hepatitis Ctreatment with interferon alpha, ribavirin and amantadine in naive patients.

Adding amantadine to the standard anti-HCV treatment can improve sustained response rates in chronic hepatitis C.

Screening for brain metastasis in patients with stage III Non-Small Cell Lung Cancer: Has Magnetic Resonance Imaging an additive value compared to contrast enhanced Computed Tomography of the brain Incorporated in the staging whole body 18FDG-PET-CT scanning?

We hypothesise that there is no clinically relevant additive value of post contrast MRI to contrast enhanced computed tomography (CE-CT) of the brain when both are performed in standard work-up, including 18FDG-PET-CE-CT, in detecting asymptomatic…

The role of free fatty acids in the glucose-lowering effects of thiazolidinediones.

Thiazolidinediones (TZD's, Pioglitazone) lower free fatty acids (FFA) in plasma via increased insulin sensitivity (=decreased lipolysis) in adipose tissue. The decrease in plasma FFA results in increased insulin sensitivity in skeletal muscle.…

EPA Incorporation and Immune responses after nutritional supplementation in Cancer patients.

It is expected that one week of supplementation with the study product will contribute to an improved immune response and to increased incorporation of EPA and DHA in white and red blood cells and plasma.

The effectiveness of PratenOnline.nl.

The treatment of PratenOnline is more effective in terms of depressive symptoms and competence than a wait listed group.

IMMEDIATE study

intravenous immunoglobulins will induce a fast and effective response in patients with newly diagnosed idiopathic inflammatory myopathies. Also, the treatment will be generally safe. Furthermore, this pilot study will show feasibility with respect…

Career-directed people management training

Hypothesis 1 (H1): At Time 2, line managers who participate in a people management program will report higher levels of people management behaviour (a), and professionals will report higher levels of people management behaviour as implemented by…

An open label randomized controlled study in elderly subjects with previously untreated acute myelogenous leukaemia, comparing treatment groups randomised to receive daunorubicin and cytarabine or daunorubicin, cytarabine and PSC-833.

The hypothesis to be tested is that the outcome in arm B is better than in arm A.

Evaluation of the i-gel supraglottic airway.

In this study we will evaluate the use of the i-gel for airway management during induction and maintenance of anesthesia. The i-gel will be compared to the standard laryngeal mask (La premiere laryngeal mask, figure 2) now used in our institute. In…