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Study Towards the Effects of Post discharge nutrition on growth and body composition of infants born

To study the effects of post dicharge nutrition on the growth, body composition, metabolism and neurodevelopment of premature infants . To study the effects of catch-up growth on the body composition, metabolism and neurodevelopment of premature…

Risk perception, informed decision making, and psychological well-being of pregnant women who are offered prenatal screening for congenital defects.

N/A

Exenatide-study.

Exenatide improves first and second phase insuline secretion compared to insulin glargine.

Open label, comparative, randomized, multicenter, study of trastuzumab given with docetaxel versus sequential single agent therapy with trastuzumab followed by docetaxel as first-line treatment for Her2neu+++ metastatic breast cancer patients.

Although combined treatment will probably lead to higher response rates,sequential treatment may result in a similar time to progression in the presence of less side effects and a better quality of life in a significant number of patients.

Fall prevention implemented in primary healthcare

H0: Implementation of a systematic and targeted screening of fall risk among independently living frail older people in primary care will not influence on the number of referrals to existing evidence-based fall prevention interventions. H1:…

Metabolic day-night rhythms in type 2 diabetes.

Type 2 diabetes is a major threat to human health. Previous studies suggest an altered circadian rhythm of glucose metabolism, leukocyte clock gene expression and hemostasis in patients with type 2 diabetes, but type 2 diabetes patients have never…

Fatigue after prophylactic cranial irradiation in small cell lung cancer patients

Fatigue will be at its worst 2 to 3 weeks after prophylactic cranial irradiation (PCI)

Randomised controlled trial to evaluate tolerance, intake and safety of a new high-energy high-protein oral nutritional supplement in elderly subjects in need of oral nutritional support.

Tolerance to new high-energy high-protein oral nutritional supplement is equal to standard high-energy high-protein oral nutritional supplement.

Acute endovascular treatment to improve outcome of ruptured aortoiliac aneurysms.

Acute endovascular treatment improves outcome of ruptured aortoiliac aneurysms.

Evidence-Based Medicine for occupational physicians, innovation and implementation in practice.

The intervention will lead to more knowledge, better skills and higher professional competence compared to the control group.

Prevention of Lower Urinary Tract Symptoms (LUTS) in elderly males; the effects of an increased urine output on symptoms and bladder functioning.

Increasing the urine output will lead to improved bladder function and to a decrease in symptom severity.

ICAD: Clinical validation study of a new algorithm for oral anticoagualant dosing.

The equations used by most current algorithms are usually based on a simple pharmacodynamic model, which implies a linear function between the INR and the dosage. Our new algorithm consists of two sub models in which the first sub model describes…

Lessons and needs arising from experienced moral stress and moral dilemmas at the ICU during the COVID-19 pandemic

Employees of the ICU experienced more moral issues and moral dilemmas during the first wave of COVID-19. There are differences in experienced moral issues and dilemmas between professions (e.g. doctor vs. nurse).

Jump training and collagen supplementation for bone health

Long-term (18 weeks) jump training combined with collagen supplementation will increase BMD in elite cyclists.

Patient Safety Education for Residents.

N/A

Rotterdam Aphasia Therapy Study - 2.

1. Cognitive linguistic therapy (CLT) is more effective than no-CLT; 2. CLT applied 0-3 months post onset is more effective than applied 3-6 m.p.o.

Clock gene expression in hemodialysis patients.

A disruption of the biological clock is presumed in hemodialysis patients since they frequently suffer from sleep problems and lack a nocturnal melatonin surge, which is a reasonable readout for disturbed clock performance. The origin of these…

A study on peripheral motor nerve excitability in patients with ALS

Patients with ALS are routinely prescribed riluzole, the only registered drug for the treatment of ALS. This study will evaluate the concentration-effect relationship of riluzole (100 mg) and retigabine (300 mg) on axonal excitability measures. In…

Dagboekstudie bij schouderprothesen: de eerste acht weken na de operatie en belangrijke voorspellers voor korte- en lange termijn uitkomsten

Primary Objective  To describe how patients experience the first eight weeks after shoulder arthroplasty, regarding pain and pain medication, shoulder function and quality of life.  To determine the direct effect of patients' expectations on…

Hoofdpijn bij mensen met klachten vanuit het kaakstelsel.

In TMD patients with concomitant headache, t is hypothesized that treatment of the TMD complaints will have a positive effect on the headache as well. The effect size is expected to depend on the type of headache, with the strongest effect for…