16235 resultaten
Based on its ability to reduce expression and activity of the matrix metalloproteinase 9 doxycycline has been proposed as a means of stabilizing abdominal aneurysms. Yet as progression of AAA is related to increased collagen turnover we hypothesized…
Since previous studies suggest that an influenza vaccination is probably less or even not effective in rituximab treated RA patients, we want to investigate if this also holds true for this new vaccine against the H1N1 virus.
Influence of oxynorm melt tablet versus paracetamol melt tablet on pain relief in healthy volunteers
The main aim of the study was to quantify the temporal antinociceptive profile of administration of oxynorm orodispersible tablets versus orodispersible paracetamol tablets. We hypothesize that oxycodone produces greater analgesia than the active…
30% improvement is the minimal effect found in previous microneedling studies, based on this studies we expect to find a 7.5 point improvement on the POSAS total score
The purpose of this study is to conduct a randomized controlled trial with the psycho-educational preventive intervention program ‘En nu ik…!’ (Now it’s time for me!) and the control program ‘Jij hoort erbij’ (You belong too). In the intervention…
There are two research questions: 1. What is the effect of a minimal CBT intervention for CFS in primary care carried out by trained social psychiatric nurses? 2. What are the characteristics of CFS patients who do not improve by a minimal…
An intervention with a fortified drink containing iron, zinc, vitamin A, vitamin C, folate, vitamin B-12 and B-6 and/or omega-3 polyunsaturated fatty acids over one year can improve cognitive performance in Australian well-nourished children and…
We hypothesize that an electronic nose can discriminate the VOC pattern in exhaled breath between patients with non small cell lung cancer (NSCLC) and breast cancer.
We hypothesize that the % responders 2-6 weeks after the last vaccine dose in patients with ultra-low dose RTX (1x 500 mg or 1x 200 mg every 6 months) is significantly higher compared to patients treated with low-dose or registered dose RTX. We also…
A higher (animal) protein and a higher essential amino acid intake (especially leucine) are associated with less decline in mid-thigh muscle cross-sectional area over a 5-year period.
Het bepalen van de haalbaarheid om met ICG de chirurg optisch te geleiden naar de schildwachtklier bij pediatrsiche patienten met een melanoom of sarcoom ter plaatse van het hoofd/hals/romp, paratesticulair of extremiteit. De…
The objective of this proof-of-concept study is to test in no-option CLI patients whether ARA 290 (a) reduces limb pain, (b) reduces signs of local and systemic inflammation, and (c) promotes wound healing.
The use of a new protocol of exercise testing with use of blood pressure measurement, near infrared spectroscopy and pedal force measurement will improve the diagnostic value of the current decision algorithm used to diagnose functional iliac flow…
Pelvic floor muscle training supported by vaginal and abdominal biofeedback, serious games and a web-portal is non-inferior to pelvic floor muscle training alone.
Our hypothesis is, that the extrinsic mechanism in the etiology of SIS is only valid for a subgroup of patients; complaints of SIS can be caused by 1) a pathologic pattern of arm-scapula movements caused by a disrupted balance in muscle forces,…
We hypothesize that induction of labour in patients with gestational hypertension, deteriorating chronic hypertension or preeclampsia between 34 and 37 weeks reduce the maternal morbidity but might increase the RDS rate in neonates, compared to…
We hypothesize that the CPA Talking-with-children-intervention will have a beneficial effect on the mental health and quality of life of maltreated children. We expect that children who participate in the CPA investigation (CPA Talking-with-…
We hypothesize that it is possible to culture circulating tumor cells obtained by leukapheresis into organoids.
Synflorix (PCV10) and Prevenar-13 (PCV13) are comparable in inducing cellular and humoral immune responses in Dutch infants for the 10 overlapping serotypes in the vaccines. Differences are expected for three serotypes that are present in Prevenar-…
The aim of this study is to pass of the care for patients with fibromyalgia more efficiently through the cooperation of the rheumatologist and the nurse specialist. Because of this, the rheumatology outpatient department can be relieved partly,…