16235 resultaten
Dental caries lesions (with ICDAS Codes 3 and 4) can be treated by sealing, offering a less invasive and less costly treatment option with the same results as preparation and restoration of the carious lesions.
1. Cysteine is an essential amino acid for newborn preterm infants; 2. Cysteine requirements change rapidly with postnatal age; 3. The change in cysteine requirement with age is based upon cystathionase activity; 4. Intestinal cystathionase activity…
The primary objective is to demonstrate the non-inferiority of bevacizumab to ranibizumab in the treatment of patients with subfoveal CNV secondary to AMD as determined by the change in best-corrected visual acuity in the study eye from baseline to…
We hypothesise that the diet over time has become healthier and more sustainable. Our current study was set up to (1) identify the differences in food consumption and nutritional quality over the course of 20 years in the Netherlands using the…
• There is no difference in number of bonding failures between the direct and indirect bracket bonding methods • Patients favour indirect bracket bonding over direct bracket bonding • Brackets bonded with the indirect bracket bonding will have less…
To test whether implementing a bundle of specific measures during the night shifts at the A&E department improves sleep quality and general physical and psychological well-being Investigate whether this bundle of measures 6 months after…
Acetaminophen is effective in treating self-reported sleep problems, in particular insomnia.
Simular outcomes in patients with 4 implants compared with patients with 6 implants with respects to peri-implant bone level stability
We want to determine the influence and safety of probenecid on sorafenib pharmacokinetics. By inhibiting the OAT6 transporter there might be a faborable effect on Hand-foot syndrome
Antipsychotics (haloperidol) can cause acute changes in cardiovascular functions, metobolic parameters and platelet aggregation in elderly patients.
The nutritional status of patients supplemented with Renilon 7.5 for 3 months will be improved compared with patients who receive the standard treatment. Nutritional status will be assessed by a significant improvement after 3 months of treatment by…
We hypothesize that rhDNase can liquefy sputum in acute asthma resulting in less airways obstruction, reduced work of breathing, and diminished ventilation-perfusion mismatch, thereby improving symptoms, reducing the number of patients who need to…
To define the parameters and to identify new biomarkers which predict disease progression in individuals with different COPD phenotypes. To follow a subgroup of the ECLIPSE cohort the predictive values of the variables will be enhanced with an…
Participation in a health survey for elderly people (60-75 years) on risk factors for cardiovascular diseases, depression, osteoporosis and falls, followed by a subsequent personalized health advice from a community nurse on lifestyle modification…
1. Show that Growing Up Milk, as part of a healthy diet, can fill nutritional gaps, with special attention to the iron and Vitamin D levels, in young children is more efficient than a healthy diet with cow's milk; 2. Increase of the serum iron…
Primary hypotheses: 1) Pivotal Response Treatment (PRT) with the implementation of a robot is more effective compared to PRT provided by a human trainer and compared to care-as-usual only in: -promoting social and communicative skills in children…
1. When patients visit their GPs with unexplained complaints it is cost effective to follow a watchful waiting strategy of four weeks before ordering laboratory tests; 2. A systematically developed quality improvement strategy, based on barriers…
Nilotinib plus PegIFN will increase depth of response in CML patients who have stable responses above 0.01%.
We hypothesize that the response of the bronchial mucosa to nanoparticles is a critical determinant of their pathophysiological effects in humans in vivo. More specifically, we postulate that carbon nanoparticles cause dose-dependent local and…
adults. We hypothesize that test product NL-01, which is an extract from food crops enriched for IMPP-1, a compound that supports innate immune function, increases resistance to acute respiratory tract infections (ARTI) in the winter season