16235 resultaten
Continuing sulfonylurea in patients without good glycaemic control and using insulin and metformin, will diminish insulin secretion of beta-cells less than discontinuing sulfonylurea in these patients.
Compared to an online smoking cessation brochure, does participation in an online self-help smoking cessation program lead to: 1. A greater percentage successful quitters, three and six months after the start of the intervention; 2. A greater…
The Psycho-Education/Coping Skills Training is effective in reducing the negative consequences of stigma in people with a severe mental illness: 1. Increasing quality of life; 2. Improving social functioning; 3. Reducing needs for care.
This study will test the effectiveness of Virtual Reality Biofeedback Video Game DEEP in improving anxiety symptoms and related physiological arousal and appraisal patterns. It is expected that this game will lead to a greater improvement in these…
We expect that treating patients with the IlluminOss® System will result in excellent recovery
All polyethylene tibial components in total knee arthroplasty in rheumatoid arthritis patients gives durable long term results.
Laparoscopic lavage for purulent peritonitis for perforated diverticulitis leads to a 15% reduction in the combined endpoint of major morbidity and mortality, compared to resection. Resection with primary anastomosis leads to a 22% reduction in the…
Treatment of patients with respiratory complaints in the emergency department (ED) based on venous blood gas (VBG) results does not differ from treatment based on arterial blood gas (ABG) results.
5-Aminosalicylates influence the metabolism of thiopurines leading to higher levels of the pharmacological end-metabolite 6-thioguaninenucleotides.
The hypothesis is that intake of liquid carbohydrates is not compensated sufficiently by reducing caloric consumption from other foods. This leads to incomplete compensation for the energy ingested and eventually results in weight gain.
A significant difference in angular measurement is expected in weightbearing and non-weightbearing radiographs in patients with hallux valgus deformity.
Given the presumed cholinergic deficiency the cholinergic drug rivastigmine might be a suitable drug for treatment of delirium
The study is designed to demonstrate superiority of Cypher stent based on the assumption that at follow-up angiography the late loss is at least 0.15 mm smaller than the mean late loss when the Taxus stent is used.
The aims of the study are: 1. to assess the clinical utility and feasibility of AFI in surveillance colonoscopy in patients with lonngstandig UC; 2. to determine the additionalvalue of AFI in the dection of dysplasia and cancer in these patients; 3…
Double layer closure of the uterine scar using unlocked continuous running sutures reduces menstrual disorders and pain and subfertility in relation to niche development and increases QOL and improves sexual functioning.
To evaluate the validity, reproducibility and scale functioning of the Dutch clinician-based Constant-Murley (CM) score and of a Dutch patient-derived Constant-Murley score in patients with shoulder arthroplasty. To define the smallest detectable…
Treatment according to the Dutch National Guideline on the Management of Employees with Mental Health Problems by Occupational Physicians will cause less work disability than treatment according to usual care, with minimal involvement of the…
The intervention will - after succesfull implementation and adoption - lead to a reduction in BMI and body fat and improvements in biomarkers.
Because of the high colorectal cancer (CRC) risk, Hodgkin lymphoma (HL) survivors should be offered colonoscopy screening, which has the potential to reduce CRC incidence and mortality. However, the diagnostic yield, cost-effectiveness and burden of…
Intradermal yellow fever vaccination with a reduced dose will induce a sufficient protective immunological response comparable to the response elicited by subcutaneous yellow fever vaccination.