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A study to evaluate the different levels of attention and valence direction for erotic stimuli, in relation to genital and subjective sexual arousal in healthy female subjects and healthy female subjects with Female Sexual Dysfunction.

In the present placebo controlled study we will investigate the influence of valence on attention when viewing visual erotic stimuli. Especially when under the treatment condition of testosterone with sildenafil. In addition, we will investigate the…

Effects of crisis cards/plans for people with psychotic illnesses, facilitated through local patient organisation and through clinician, on the number of crisiscontacts with mental health services and the numer of (cumpulsory) admissions.

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FEmoral BOne fracture study

We expect the protein synthesis rate in (avascular) femoral bone proximal to the fracture to be lower when compared to healthy femoral bone.

Does booster influenza vaccination improve vaccination efficacy in patients with quiescent systemic lupus erythematosus?

SLE patients show a decreased humoral immune response to influenza vaccination, as compared to healthy controls. Furthermore the use of immunosuppressives is of influence on vaccination immunogenicity, it has been demonstrated that the use of drugs…

Radiotherapy with or without ibandronate in the treatment of painful bone metastases of prostate cancer.

The purpose of this study is to evaluate the efficacy of oral ibandronate (versus placebo) added to the standard radiotherapy regimen for painful bone metastases to reduce pain, to reduce the need of analgesics, and to reduce skeletal-related events…

A Phase I/II study of Azacitidine (Vidaza®) in pediatric patients with relapsed high-grade pediatric MDS or JMML.

There is clear medical need in pediatric high-grade MDS and JMML to control disease pre-SCT without the disadvantages associated with intensive chemotherapy. So far no agents have been successfully applied in this window, or are specifically…

Amsterdam Wrist Rules

With implementation of the AWR we expect a reduction in the total amount of radiographs requested, without missing any clinical relevant fractures. We also expect a reduction in overall waiting times at the ED and a total amount of cost savings…

School transition management in children with Autism Spectrum Problems

Both two transition management interventions will be effective in the reduction of the school transition problems of children with ASP. We have no hypothesis about which intervention will be most effective in the reduction of childhood…

Embryo selection by metabolomic profiling.

Ho: the life birth rate in patients after SET with only morphological embryo selection is equal to patients with metabolomic profiling added to morphological selection. H1: the life birth rate in patients after SET with only morphological embryo…

The effect of application of 0.12% chlorhexidine gel-toothpaste compared to 0.12% chlorhexidine mouthwash and regular toothpaste in a 3 day non-brushing model on plaque accumulation.

Tray application of 0.12% chlorhexidine gel-toothpaste has more than 15% better effect on ¡®de novo¡¯ plaque accumulation compared to tray application of regular toothpaste in a 3 day non-brushing model.

A randomized, double-blind, placebo-controlled, multicenter trial to evaluate the clinical efficacy of a single intrapyloric injection of botulinum toxin type A (Botox®) in patients with Idiopathic Gastroparesis. The BIG study.

Several open-label pilot studies have shown a promising effect of intrapyloric botulinum toxin injection on symptoms in severe gastroparesis. However, data from randomized, double-blind, placebo-controlled studies are not yet available. We intend to…

Reducing Cancer-Related Fatigue: Untire App as an Evidence-Based mHealth Solution

The Untire app will create awareness by proving psycho-education and will give insight in ones’ energy levels, ones’ thoughts and behaviors in relation to energy levels and provides exercises that help users to challenge ineffective thoughts and…

Joint distraction in the treatment of knee osteoarthritis: efficacy and underlying mechanisms.

A two month distraction period results in similar clinical beneficial effects as a three month distraction period.

Randomized study with a run-in dose-selection phase to assess the added value of lenalidomide in combination with standard remission-induction chemotherapy and post-remission treatment in patients aged 18-65 years with previously untreated acute myeloid leukemia (AML) or high risk myelodysplasia (MDS) (IPSS-R risk score > 4.5)

The hypothesis to be tested is that arm B is tolerable and that the outcome in arm B is better than in arm A.

Development and introduction of a pediatric liquid formulation of
6-mercaptopurine for treatment of leukemia.

6MP treatment in pediatric ALL patients can be improved by developing a pediatric oral drinking solution of 6MP, assessing its bioequivalence, and -when successful- introducing the new formulation nationwide.

Prodromal symptoms and early intervention to prevent a relapse.

Could early treatment of prodromal symptoms prevent or postpone a psychotic relapse in schizophrenia?

Patient Safety and Complex Care.

The rate of unintended events and avoidable harm for elderly hip fracture patients can be reduced by the introduction of three integrated interventions directed at the structure of the handover process, the role of the patient in the care process…

Mechanical bowel preparation for elective colorectal surgery.

Mechanical bowel preparation (MBP) is common practice in elective colorectal surgery. In recent literature the value of MBP is subject of discussion. This non-inferiority, randomized study evaluates the value of MBP before colorectal surgery.

A Phase II randomized multicenter study to assess the efficacy of lenalidomide with or without erythropoietin and granulocyte-colony stimulating factor in patients with low and intermediate-1 risk myelodysplastic syndrome.

The hypothesis to be tested is that the outcome in arm B is better than in arm A.

Phase II trial of combination therapy with oxaliplatin and capecitabine in patients with advanced esophageal cancer.

For patients with metastatic or local-regional unresectable esophageal carcinoma there is no alternative treatment. In this trial it is studied whether combination chemotherapy with oxaliplatin and capecitabine prolongs survival and improves quality…