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Effect of thoracic epidural anesthesia (TEA) on right ventricular function and ventricular-pulmonary coupling.

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An open randomised study comparing efficacy of maintenance therapy with imiglucerase at a frequency of once every four weeks versus the original schedule (once every one or two weeks) in adult type I Gaucher disease patients.

To compare the efficacy of maintenance therapy with an equal monthly dose of imiglucerase when administered at a frequency of once every four weeks versus once every one or two weeks, in adult type I Gaucher disease patients in stable and good…

Lifestyle Interventions for Severe Mentally Ill Outpatients in the Netherlands.

1. A multidimensional lifestyle intervention, including aspects of increased awareness, motivation, self-management, diet, exercise, and a supportive environment, improves or prevents deterioration of the cardiometabolic risk factors of SMI…

Radiostereometric analysis as early predictor for aseptic loosening of the femoral component in total hip arthroplasty: A double meta-analysis.

The aim of the meta-analysis is to investigate the early predictive value of migration measured by RSA 1 year post-operatively for revision for aseptic loosening of the femoral component in THA and to compose migration thresholds for safe and…

Anti-TNF-alpha (Infliximab) in Complex Regional Pain Syndrome.

Infliximab counteracts the increased synthesis of tumor necrosis factor alpha (TNF-alpha), after which inflammation will decrease and recovery of the disease occur.

Elective laparoscopic appendectomy for chronic right lower abdominal pain;
outcome of a prospective randomised
double-blind controlled surgical trial.

Elective laparoscopic appendectomy is a usefull procedure in patients with chronic or recurrent right lower abdominal pain.

Mycophenol mofetil in Antiretroviral Naïve patients 2 (MAN2 study).

During chronic HIV-1 infection the immune system is chronically hyperactivated. This hyperactivation is considered as the main cause of CD4+ T-cell loss. Furthermore, HIV replicates most efficiently in activated CD4+ T-cells. In this study we try to…

Mylotarg as salvage treatment for children with relapsed acute myeloid leukemia.

To assess whether children with relapsed/refractory AML, who do not achieve remission or relapse after treatment with the Relapsed AML 2001/01 standard reinduction protocol (fludarabine, cytarabine and GCSF with or without DaunoXome�), can be…

CPAP titration at birth

We hypothesize that an initial CPAP level of 15 cmH2O followed by down titration to 8 cmH2O is better CPAP strategy for preterm infants at birth when compared to the currently used initial CPAP level of 5 cmH2O followed by up-titration to 8 cmH2O…

"Phobias under control".

We want to test the hypothesis that internet based guided self-help is not more expensive and not less effective than usual care for patients with phobias.

Randomized induction and post induction therapy in older patients (>= 61 yrs of age) with acute myelocytic leukemia (AML) and refractory anemia with excess of blasts (RAEB, RAEB-t).

The first hypothesis to be tested is that the outcome in arm B is better than in arm A. The second hypothesis to be tested is that the outcome in arm 2 is better than in arm 1.

Mannitol inhalations as faster procedure for testing of airways hyperresponsiveness.

Measurement of airways hyperresponsiveness by mannitol (Aridol©) as compared to methacholine saves time to the lung function technician, while being as sensitive to discern hyperresponsive from normo-responsive, and being at least equally acceptable…

Calcineurin-inhibitor Nephrotoxicity and Efficacy Study.

We believe that a routine graft biopsy at 6 and 12 months together with graft function represents the best surrogate marker for late graft loss.

Transfusion induced complications = transfusion associated complications ? study.

Does removal of allogeneic white blood cells by filtration reduce postoperative complications?

EMDR versus Cognitive Behavioral Writing Therapy (CBWT): A RCT.

Treatment of posttraumatic symptoms with EMDR as well as with CBWT will lead to symptom reduction in the short and long term. We hypothesize that EMDR will lead to faster improvements in PTSD symptoms and that the effects in the end will be equal.

The effect of pulse rate on temporal resolution and speech intelligibility in cochlear implant users

CI pulse rate is known to affect temporal resolution and speech intelligibility. Based on literature it is hypothesized that low pulse rates decrease temporal resolution, but increase speech intelligibility.

As voor echogeleid infuus prikken

Is voor het verkrijgen van echogeleide IV toegang een korte as benadering of een lange as benadering superieur wanneer deze wordt uitgevoerd door SEH-verpleegkundigen zonder ervaring met echografie.

A randomised clinical trial assessing the additional value of ovarian hyperstimulation in intrauterine insemination for couples with an abnormal post-coital test.

We hypothesized that controlled ovarian hyperstimulation (COH) is of additional value to IUI in couples with a cervical factor and a poor prognosis, i.e. < 30% spontaneous pregnancy chance in the next year.

LDL cholesterol in zeer hoog risico patiënten

PENELOPE onderzoekt welk cohort van een sub-populatie hoog risico patiënten na een Acuut Coronaire Syndroom (ACS) bij het strikt volgen van de richtlijn in drie stappen niet de beoogde lipide streefwaarden behaalt. De studie volgt de reguliere…

Hand instruments are better accepted than rotary instrumentation for restoring tooth cavities in people with disabilities.

The ART approach is more suitable than conventional restorative treatment in people with disabilities