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Stop or Go? Relapse prevention training with guided tapering of antidepressants during pregnancy. A pragmatic multicenter RCT to investigate risk and benefits for mother and child.

1) Tapering of SSRIs with added preventive cognitive therapy (CT) increases the risk of clinically relevant maternal relapse of depression in excess of [absolute] 15% compared to continuation of SSRIs. If rejected, then discontinuation is deemed non…

Dopamine on top of standard treatment for patients with exacerbation of Heart Failure, at home situation.

This study will investigate whether 24 hour dopamine infusion reduces the need of hospital admission for patients with exacerbation heart failure.

"The Medical Emergency Team (MET):
Hospital Outcomes after a Day" study

Patients subject to MET review have a high in-hospital mortality (20%). Thus, understanding the outcome of patients within the first 24hr of MET review is important in developing quality improvement and interventional studies to reduce this…

The psychological well-being and health-related quality of life of patients admitted to the hospital with COVID-19.

We hypothesized that patients admitted to the hospital during this pandemic period with a suspected or confirmed SARS-CoV2 infection, have a high risk to develop long-term or persistent symptoms of PTSD, anxiety and depression, which are associated…

PRESERVE TRIAL:
Pancreatic beta-cell dysfunction REStorEd by Rosiglitazone and Valsartan Effects. A 52-week randomized controlled factorial study in subjects with IFG and/or IGT.

Amendment 2007: PancREatic beta-cell dySfunction rEstoRed by Valsartan Effects – PRESERVE Study.

Amendment 2007: In stead of two medicaments (Rosiglitazon and valsartan), only valsartan has been completed. Due to negative publicity, Rosiglitazon was stopped. Target number of participant is thereby decreased from 144

Type 2 diabetes is cause by progressive beta-cell dysfunction against a background of obesity and insulin resistance in susceptible individuals. Peroxisome proliferator-activated receptor (PPAR) gamma-mediated mechanisms are involved in the…

The efficacy of cognitive behavior therapy and aerobic exercise training for decreasing experienced fatigue in patients with facioscapulohumeral dystrophy.

Aerobic exercise therapy (AET) and cognitive behavioral therapy (CBT) are hypothesized to be both more effective in improving activity level and, with that, decreasing experienced fatigue of FSHD patients compared to the usual care. The maintenance…

Screening for risk of posttraumatic stress disorder in children and parents after an accident.

Develop a screening tool to identify children at risk of posttraumatic stress disorder after an accident.

Effects of a pain consult and patient education and monitoring: a prospective study in oncology patients.

It is hypothised that a pain consult at the specialized pain clinic in combination with Patient Education Program is more effective in reducing average pain intensity compared to a pain consult alone. A pain consult at the specialized pain clinic is…

The influence of apical periodontitis on the concentration of inflammatory mediators in peripheral blood plasma and the metagenomic profiling of endodontic infections.

The plasma concentrations of inflammatory mediators of AP subjects are similar to those of non-AP controls and elimination of the endodontic infection does not result in changes of the systemic inflammation. Finally ) to investigate the microbiome…

Effect of Celecoxib on reponse, progression-free and overall survival, when added to standaard first line chemotherapy in advanced ovarian cancer.

Primairy Objectives: - To evaluate the antitumoral efficacy of celecoxib in combination with docetaxel/carboplatin in terms of: a) response (cCR, cPR, NC, PD) b) progression-free survival Secundairy Objectives: -To evaluate the safety and…

The Effectiveness of an Online Health Training on Optimizing Health in a Healthy Population

The aim of this study is to investigate an abridged version of an online health training, based on cognitive behavioral therapy components, that is focused on the optimization of health. It is expected that this online health training will have a…

Prevention of anxiety and depression in the elderly.

The stepped care approach will lead to a significantly reduced incidence of clinical anxiety and depression in two years and will reduce symptoms level compared to usual care.

Immunomonitoring of Cyclosporin A in healthy volunteers

This study aims to apply state-of-the-art immune tests quantifying the immunosuppressive state in individuals, and the relationship between these pharmacodynamic tests and the pharmacokinetic profile (in whole blood and intracellular) after a single…

Effectiveness of Preventive Coaching.

1. A screening instrument, consisting of predictive factors, can be used to predict which employees are at risk for sickness absence due to psychosocial health complaints; 2. Coaching is effective in preventing sickness absence and improving general…

Evaluation of a group training for adolescents (Emotion Regulation Training) with emotion regulation problems.

Adolescents with emotion regulation problems who followed the Emotion Regulation Training will show improvement on the following items: 1. Symptoms of emotional dysregulation; 2. Positive and negative coping behaviour; 3. Stress symptoms in the…

Protection against chemotherapy induced damage in the digestive tract in childhood cancer patients.

1. TGF-beta protects childhood cancer patients against chemotherapoy induced damage in the digestive tract; 2. TGF-beta can safely be administered to childhood cancer patients.

Extremity fractures with intra-operative 3D-RX.

In this multicenter RCT we aim to investigate the quality of fracture reduction and fixation, and patient-relevant outcomes when using the intra-operative use of the 3D-RX-system as compared to the conventional 2D-fluoroscopy in patients with…

Treatment of greenstick forearm fractures in children using bandages or cast therapy.

Treatment of greenstick forearm fractures with bandages, as compared to cast therapy, will lead to a decrease of discomfort and no increase of pain complaints.

Quality of Life in Motion: A combined physical exercise and psychosocial training program to improve physical fitness in children with cancer.

1. Childhood cancer patients who follow the QLIM intervention program will: a. achieve significantly higher levels of physical fitness after the 12 week intervention compared to patients in the control group, as assessed by objective performance…

The impact of whey versus collagen protein ingestion on post-exercise myofibrillar and connective tissue protein synthesis rates

1. We hypothesize that post exercise whey protein ingestion will increase myofibrillar protein synthesis rates to a greater extent than collagen protein supplementation. 2. We hypothesize that post exercise collagen protein ingestion will increase…