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The TIKI study: Treatment with or without IVIG in Kids with acute ITP.

The primary objective is to investigate to what extent early IVIG treatment in children with newly diagnosed acute ITP reduces the risk of development of chronic disease. Secondary objectives are: 1. To estimate the alteration in the clinical…

Skeletal muscle protein synthesis in elderly after bolus intake of oral nutritional supplements.

A relatively high quantity of dietary protein is needed to stimulate muscle protein synthesis in elderly.

Clinical study to evaluate safety, tolerability and effects on the immune system of a common cold vaccine in healthy adults

Respiratory Syncytial Virus (RSV) is still the leading cause of hospitalization of children under 5 years of age. Currently, there is no effective treatment licensed for an ongoing RSV infection. Therefore, Intravacc develops a live-attenuated…

Hypothermic Oxygenated Perfusion of Liver Grafts Donated after Circulatory Death in
Liver Transplantation - A Phase 1 Clinical Trial

Two hours of end-ischemic hypothermic oxygenated perfusion via both the hepatic artery and the portal vein is feasible and safe in resuscitating liver grafts procured from donation after circulatory death donors.

Effects of a participatory work stress prevention approach in primary education in the Netherlands

At two-year follow up, employees of the intervention schools report significantly lower levels of work stress and work stress risks as compared to employees of the control schools

Study on the effects of a growing-up milk (GUM)on infections in healthy children

Consumption of the new developed GUM will decrease the incidence of upper respiratory tract infections (URTI) and/or decrease the duration of acute gastrointestinal tract infections (GITI) in Asian toddlers

A pilot, double-blind, randomised, placebo-controlled, exploratory study to investigate the safety and effect of Calf Intestinal Alkaline Phosphatase in patients with sepsis.

Unlike other potential sepsis treatments, Alkaline Phosphatase has been shown to act at the front end of the inflammatory cascade. By doing so, it eliminates the root cause of the SIRS, and prevents the progression into sepsis and septic shock.

Stop worrying.

A self help brochure will help people decrease their excessive worrying. and telephonic support will increase the effect.

Effects of low-fat vs high-fat diet on lipid accumulation in liver and skeletal muscle in overweight men.

A high fat-diet can influence IMCL and IHL in rodents and in humans, the time-course of peripheral lipid accumulation in liver and skeletal muscle while switching from a low-fat to a high-fat diet is unknown.

Diagnostic blockade of sacroiliac joint in patients with pseudoradicular low back pain.

1. In patients with non-specific low back pain, 10 ml lidocaine 2% reduce the pain more then 2 cm at the BOX-score compare to the placebo group; 2. In patients with non-specific low back pain, 9 ml lidocaine 2% with 1 ml corticosteroid (40 mg…

Behandeling van Obstipatie bij Kinderen

We expect paediatric pelvic physiotherapy in addition to conventional treatment to be more (cost)- effective than conventional treatment alone, after 8 months follow-up.

REsting enERgy Expenditure in mechanically ventilated patients in the ICU and during COnValescence: a prospective cohort study

During the convalescence phase of critical illness patients will enter an anabolic phase in which REE increases and there is a subsequent increased nutritional need.

The TURN trial, Transplantation of faeces in Ulcerative colitis; Restoring Nature's homeostasis.

We hypothesize that faecal transplantation from a healthy donor can restore the dysbiosis present in UC patients, thereby inducing remission of the chronic inflammation of the colonic mucosa.

Treatment in the Rotterdam Early Arthritis CoHort. A stratified, randomised clinical trial in patients with recent-onset arthritis.

In each stratum of probability there is a clinically and statistacally significant difference in the functional ability and disease activity score over time (area under the curve) and progression of radiological joint damage after 1 year of follow-…

Open label randomized phase III study of weekly docetaxel and docetaxel every 3 weeks in patients with metastatic breast cancer, resistant to prior chemotherapy

Compare the overall safety profile in both arms : Assess the impact of differences in toxicity profiles on the incidence of dose reduction or dose delay due to grade III-IV toxicities during treatment of patients with pre-treated metastatic breast…

Neurodevelopmental outcome after neonatal hypoglycemia: a multi-center randomized controlled trial comparing intensive treatment versus expectant glucose monitoring in 'high risk' newborns.

Current clinical practice varies widely, especially for infants with 'moderate' hypoglycemia, due to lack of methodological sound studies. This leads to both over- and under-treatment of hypoglycemic infants. This study-protocol is…

Influence of stress vulnerability on type and course of bipolar disorder.

Stress vulnerability as reflected by cortisolreceptor gene polymorphisms, influences course of bipolar disorder defined by number of episodes, physical health and cognitive functioning.

Van spiegelbeeld naar patiënt in beeld

More patients in primary care will be treated according to (evidence based) guidelines if general practices receive feedback on a patient specific level then if they receive feedback on practice level comparing recipients practice with median…

Voorkoming van nabloedingen na endoscopische mucosale resectie (EMR) van de slokdarm, twaalfvingerige darm en de dikke darm.

The application of Purastat on the woundsurface will be feasible and safe.

Does the presence of a hiatal hernia affects the efficacy of the reflux inhibitor baclofen?

The efficacy of reflux inhibitors, which block transient lower esophageal sphincter relaxations (TLESRs), to reduce acid and non-acid exposure may be hampered in the presence of a hiatal hernia, as other mechanisms of reflux become more important.