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A randomized trial in cancer-related fatigue in palliatively treated patients: protocolized patient-tailored treatment of physical symptoms (PPT) vs care as usual (CAU).

Patients receiving systematic monitoring and multidisciplinary protocolized patient-tailored treatment of physical symptoms (PPT) are expected to show greater improvement on general fatigue compared to patients receiving care as usual (CAU).

Prevention of Adolescent Social and Test Anxiety.

1. Cognitive behavioural group therapy is more effective than no intervention in prevention of social anxiety and related psychological problems; 2. Computer-based BiasRetraining is more effective than no intervention in prevention of social anxiety…

Souvenir II.

Dietary management of nutrient deficiencies with the medical food under study has a positive effect on memory performance in patients with mild Alzheimer’s Disease.

The Diabetes Guidelines Implementation in Hospitals Study.

A patient centred or a porfessional directed intervention to improve adherence to diabetes guidelines in hospitals are more (cost) effective compared to usual care.

Physiotherapy, is there a difference?
Consequence of less movement in patients with ankylosing spondylitis.

Consequence on the mobility of patients who have akylosing spondylitis due to not paying for the consult of the physiotherapist by the health insurance of the patient.

Effect of blue light from electronic devices on melatonin and sleep/wake rhythms in high school children

ZEUS study.

N/A

How can we improve the blood flow to the brain during the construction of a bypass in the brain?

We hypothesize that cardiac output rather than blood pressure is essential for adequate cerebral perfusion during and after cerebral revascularization.

Post-Operative Pain prevention after hepato-pancreato-­biliary surgery: continuous
sUbfascial infiltration orePidural analgesia? a randomized controlled non-­inferiority multicenter
trial

Post-operative pain prevention with CSWI+PCA provides similar analgesia (measured by OBAS) in comparison to PCEA with shorter total operation time and shorter length of hospital stay.

The Staphylococcus aureus bacteria with insensitivity for methicillin antibiotics: a search for new risk factors and renewel of the guidelines / De Staphylococcus aureus bacterie met ongevoeligheid voor meticilline antibiotica: Een zoektocht naar nieuwe risicofactoren en vernieuwing van de richtlijnen.

The current rise of CA-MRSA in the Netherlands is due to them all being MRSA of Unknown Origin (MUO). We do not know the risk factors yet of these. If we do, the CA-MRSA will drop.

Acute Achilles tendon rupture: Minimally invasive surgery versus non operative treatment, with immediate full weight bearing. Design of a randomized controlled trial.

The study is designed to evaluate the effectiveness of conservative treatment in reducing complications when treating acute Achilles tendon rupture.

Study to assess the accuracy of two continuous glucose monitors in relation to the microcirculatory function at the adult intensive care.

The most severely ill patients have the poorest peripheral tissue perfusion and oxygenation, which will negatively influence the accuracy of continuous glucose monitoring measurements.

The effect of ondansetron, a 5-Ht3 receptor antagonist, on fatigue severity and functional impairment in CFS-patients.

Accumulating data in the literature support an important role for serotonin, in the neurobiology of CFS. Neuroendocrin and neuropharmacological studies point to an up-regulated or hyperresponsive serotonin system. Positive reports of the use of…

The AddictionBeater: a music serious game to "beat" your drive towards alcohol

a) What are the effects of the AddictionBeater on alcohol-related approach bias and implicit associations? Participants completing the AddictionBeater and the non-gamified real CBM training would show a greater reduction in alcohol-related approach…

Exploring alternative wound care treatment for percutaneous gastrostomy site infection: A prospective, randomized, open, blinded end-point (PROBE) design.

Modern dressings containing silver are more effective than topical antibiotic treatment for healing of PEG-site infections.

Phase II study of 18F fluorothymidine positron emmission tomography (FLTPET) in the follow up of glioblastoma multiforme patients treated with combined radiotherapy and chemotherapy.

The aim of this study is to assess the ability of PET using [18F] fluorothymidine (FLT), an imaging biomarker, performed at week 10 of treatment can discriminate between pseudo progression and true progression as measured by MRI at 10 and 22 weeks,…

PRESERVE TRIAL:
Pancreatic beta-cell dysfunction REStorEd by Rosiglitazone and Valsartan Effects. A 52-week randomized controlled factorial study in subjects with IFG and/or IGT.

Amendment 2007: PancREatic beta-cell dySfunction rEstoRed by Valsartan Effects – PRESERVE Study.

Amendment 2007: In stead of two medicaments (Rosiglitazon and valsartan), only valsartan has been completed. Due to negative publicity, Rosiglitazon was stopped. Target number of participant is thereby decreased from 144

Type 2 diabetes is cause by progressive beta-cell dysfunction against a background of obesity and insulin resistance in susceptible individuals. Peroxisome proliferator-activated receptor (PPAR) gamma-mediated mechanisms are involved in the…

The efficacy of cognitive behavior therapy and aerobic exercise training for decreasing experienced fatigue in patients with facioscapulohumeral dystrophy.

Aerobic exercise therapy (AET) and cognitive behavioral therapy (CBT) are hypothesized to be both more effective in improving activity level and, with that, decreasing experienced fatigue of FSHD patients compared to the usual care. The maintenance…

Screening for risk of posttraumatic stress disorder in children and parents after an accident.

Develop a screening tool to identify children at risk of posttraumatic stress disorder after an accident.

Stop or Go? Relapse prevention training with guided tapering of antidepressants during pregnancy. A pragmatic multicenter RCT to investigate risk and benefits for mother and child.

1) Tapering of SSRIs with added preventive cognitive therapy (CT) increases the risk of clinically relevant maternal relapse of depression in excess of [absolute] 15% compared to continuation of SSRIs. If rejected, then discontinuation is deemed non…