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MEG in Parkinson¡¯s disease patients with DBS

DBS-related cognitive decline and psychiatric side-effects in Parkinson's disease (PD) patients can be studied from a functional- and structural network point of view. We will characterize functional and structural brain networks in PD patients…

The TIKI study: Treatment with or without IVIG in Kids with acute ITP.

The primary objective is to investigate to what extent early IVIG treatment in children with newly diagnosed acute ITP reduces the risk of development of chronic disease. Secondary objectives are: 1. To estimate the alteration in the clinical…

Early Intervention with Eye Movement Desensitization and Reprocessing to reduce PTSD symptom severity: A randomized controlled trial in recent rape victims.

Victims of rape report significantly less PTSD symptoms at 4-,8- and 12-weeks follow up, after two sessions of Early EMDR therapy compared to TAU.

PRACTISS Asthma.

We hypothesize that selfmanagement support via an internet based service in addition to usual care will improve health related quality of life in patients with severe asthma who have participated pulmonary rehabilitation in specialized asthma…

A Phase 1, Single-Center, Open-Label, Induction Dose Study of ABP-700 in Healthy, Adult Subjects

•To assess the safety and tolerability of induction doses of ABP-700 and determine dosing regimens that reliably produce drug induced unconsciousness and the pharmacodynamic conditions necessary for induction of general anesthesia with ABP-700 alone…

Digital Cardiac Counseling Trial: DCC Trial

Pre-operative comprehensive digital Cardiac Counseling (prehabilitation) will reduce the cumalative incidence of MACE at 1 year postoperatively in patients operated for a cardiovascular procedure.

Skeletal muscle protein synthesis in elderly after bolus intake of oral nutritional supplements.

A relatively high quantity of dietary protein is needed to stimulate muscle protein synthesis in elderly.

Learning by moving

In this RCT we investigate the effects of two school-based physical activity interventions (aerobic exercises versus coordinative exercises) in primary school children on executive functions and academic achievement. We hypothesize that both aerobic…

E-mental health treatment for patients with eye diseases (E-PsEYE): RCT

E-PsEYE in comparison with usual care is cost-effective.

Clinical study to evaluate safety, tolerability and effects on the immune system of a common cold vaccine in healthy adults

Respiratory Syncytial Virus (RSV) is still the leading cause of hospitalization of children under 5 years of age. Currently, there is no effective treatment licensed for an ongoing RSV infection. Therefore, Intravacc develops a live-attenuated…

A randomized phase II multicenter study to assess the tolerability and efficacy of the addition of ibrutinib to 10-day decitabine in UNFIT (i.e. HCT-CI >= 3) AML and high risk myelodysplasia (MDS) (IPSS-R > 4.5) patients aged >= 66 years.
A study in the frame of the masterprotocol of parallel randomized phase II studies in UNFIT-older AML/high-risk MDS patients.

To assess in a randomized comparison the effect of Ibrutinib added to 10-day decitabine treatment on the cumulative CR/CRi rate after 3 cycles. To assess the safety and tolerability of Ibrutinib added to 10-day decitabine treatment for AML (…

Screening for transient leukemia in children with Down syndrome.

Prevention of the progression of TMD to ML-DS by chemotherapeutical profylaxis can be possible.

Motor imagery training in children with Developmental Coordination Disorder

Hypothermic Oxygenated Perfusion of Liver Grafts Donated after Circulatory Death in
Liver Transplantation - A Phase 1 Clinical Trial

Two hours of end-ischemic hypothermic oxygenated perfusion via both the hepatic artery and the portal vein is feasible and safe in resuscitating liver grafts procured from donation after circulatory death donors.

Effects of a participatory work stress prevention approach in primary education in the Netherlands

At two-year follow up, employees of the intervention schools report significantly lower levels of work stress and work stress risks as compared to employees of the control schools

Study on the effects of a growing-up milk (GUM)on infections in healthy children

Consumption of the new developed GUM will decrease the incidence of upper respiratory tract infections (URTI) and/or decrease the duration of acute gastrointestinal tract infections (GITI) in Asian toddlers

Cognitive behavioral therapy given by psychiatric nurse practitioners with patients with sleepingdisorder.

Study the effects of short-term cognitive behavioral therapy (CBT) given by psychiatric nurse practitioners with familiar patients with chronic benzodiazepine use and new patients in the family practice with sleepingdisorders.

A pilot, double-blind, randomised, placebo-controlled, exploratory study to investigate the safety and effect of Calf Intestinal Alkaline Phosphatase in patients with sepsis.

Unlike other potential sepsis treatments, Alkaline Phosphatase has been shown to act at the front end of the inflammatory cascade. By doing so, it eliminates the root cause of the SIRS, and prevents the progression into sepsis and septic shock.

Stop worrying.

A self help brochure will help people decrease their excessive worrying. and telephonic support will increase the effect.

Effects of low-fat vs high-fat diet on lipid accumulation in liver and skeletal muscle in overweight men.

A high fat-diet can influence IMCL and IHL in rodents and in humans, the time-course of peripheral lipid accumulation in liver and skeletal muscle while switching from a low-fat to a high-fat diet is unknown.