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6MP treatment in pediatric ALL patients can be improved by developing a pediatric oral drinking solution of 6MP, assessing its bioequivalence, and -when successful- introducing the new formulation nationwide.
The hypothesis to be tested is that the outcome in arm B is better than in arm A.
Binocular patching in combination with posture adherence is superior to posture adherence alone in achieving visualization of the superior fundus quadrants following a vitreous hemorrhage.
Smoking cessation after development of coronary heart disease improves prognosis more than any other treatment and prevents future cardiovascular diseases. This study aims to provide hospitalized coronary heart disease patients who smoke with proven…
In patient with clinically suspected appendicitis, imaging is needed to substantiate the clinical diagnosis. Imaging accuracy of US and CT is suboptimal, and the associated use of ionizing radiation and iodinated contrast medium are major drawbacks…
Microspirometry result in a higher proportion of diagnostic spirometric assessment to objectify the existence or absence of a chronic airflow obstruction within 3 months after a patients at risk for COPD visited the GP compared to usual care.
The primary objectives of this project are: - Identify neural correlates and behavioural measures that underlie cognitive processes that perpetuate CFS symptoms - Identify neural mechanisms of change that mediate successful CBT.
This study will explore the feasibility of post-transplant panobinostat combined with decitabine after reduced intensity conditioning (RIC) alloHSCT in patients with (very) poor-risk AMLor RAEB with IPSS >= 1.5 (AML/RAEB). While recent…
To assess the effect of an Amino Acid based Formula (AAF) with synbiotics on the balance of major constituents of the gut microbiota, specifically Bifidobacteria vs. Clostridial groups.
The Solace European Confirmatory (SOLECT) Trial is designed to determine whether the Solace Bladder Control System is safe and effective for the treatment of Stress Urinary Incontinence (SUI) in adult females.
Fatty acids supplementation can: 1. Reduce or prevent triglycerides increase; 2. Reduce inflammatory markers concentration.
In Gabon, antimalarial drugs are widely available in both the private as well in the public sector and often self-prescribed (correctly and incorrectly) for the many febrile episodes attributed to malaria. Insufficient facilities to check the…
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The percentage of successful PIV insertions at the first attempt in newborns will increase with the Veinviewer® and/or Astodia®, two vascular imaging devices
It is expected that modafinil improves cognitive functioning in abstinent alcohol dependent patients, increases time to first relapse and reduces relapse rates and relapse severity. In addition, it is expected that participants with different…
We expect an improvement in psychological flexibility and a decrease in pain interference in daily life or in fatigue. Furthermore, we expect a decrease in depression and anxiety symptoms.
Think different: effectiveness of an online training for children with obsessive-compulsive disorder
The aim of the present study is to improve treatment for children with OCD by adding an online Cognitive Bias Modification-Interpretation (CBM-I) training as a pre-treatment to cognitive behavioural therapy (CBT). CBM-I is compared with a waitlist…
People with aphasia have problems with communicating. Because communication is very important in the society, these group suffers from a smaller social network, diminished social participation and as a result of this, loneliness, a loss of autonomy…
This is a dose-escalation study to determine the safe dose of clofarabine given in combination with cytarabine and liposomal daunorubicin.
The present study aims at the improvement of the treatment of children with PTSD by examining the effectiveness of a brief intensive exposure therapy (IET) for children with PTSD using a multiple baseline design (patients are randomly assigned to…