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The hypothesis is that rhGH treatment in children with KS results within 6 weeks in a change of metabolism recognizable as an increase of total energy expenditure (TEE). This change in metabolism can be used as a predictor of growth response in the…
Motor cortex or cerebellar tDCS(transcranial Direct Current Stimulation) will enhance motor skill learning in heatlhy subjects and chronic stroke survivors. Stimulating the motor cortex will result in an increase in offline learning, whereas…
Training nurses in managing challenging behavior of clients with dementia will improve their work satisfaction and decrease their work stress in the short and long term. Challenging behavior of the clients will decrease as an effect of the program.
1. The deafferentiation during spinal anesthesia changes the connectivity in resting-state networks in healthy volunteers; 2. The deafferentiation during spinal anesthesia changes pain perception and has sedetive effects.
The addition of milk protein hydrolysate and tryptophan rich proteins and/or decreasing stomach emptying rate in combination with increased satiety, will improve sleep onset and efficiency significantly as compared with the current available growing…
The number of people undergoing total hip or total knee surgery is growing. The majority of these patients has a favorable outcome with respect to pain, function and quality of life. In a small group of patients however the results are disappointing…
The objective is to identify a formulation of ModraCape001 that will release capecitabine in vivo over a time-period of about 18 hours. We hypothesize that prolonged exposure, without a high peak exposure to capecitabine, improves the benefit/risk…
Based on the human milk composition, Nutricia Research has developed a new infant formula with a new fat blend, more similar to that of human milk. This new formula is currently being studied for safety and its effects on growth. The comparator used…
Peer assessment, as a educational guideline implementation strategy, results in more improvement of evidence based reasoning than case based discussion.
The aim of the study is to compare the efficacy of per-oral endoscopic myotomy (POEM) to the efficacy of pneumodilation as the initial treatment of symptomatic idiopathic achalasia. It is hypothesized that POEM has a higher long-term efficacy than…
This study aims to investigate the effectiveness of a multicomponent intervention in promoting physical activity among adults with ID.
Treatment of active rheumatoid arthritis with rituximab will positively influence endothelial function.
Digital subtraction angiography can be performed at a lower iodinated contrast concentration than currently used, without loss of anatomical information and image quality.
It is expected that using the DEM-DISC will decrease the number of unmet needs and increase the number of met needs in people with dementia and their informal caregivers. Informal caregivers using DEM-DISC are expected to feel less burdened and will…
In euthyroid women with thyroid autoimmunity and recurrent miscarriage, levothyroxine started preconceptional, increases live births beyond 24 completed weeks by at least 20%, compared to placebo.
For patients with a diffuse large B cell lymphoma (DLBCL) the efficacy of the anti-CD20 monoclonal antibody rituximab combined with salvage chemotherapy in the second-line setting has decreased due to more effective first-line treatment with…
In adult congenital heart disease patients with exercise-induced pulmonary arterial hypertension, treatment with bosentan lowers the mean pulmonary arterial pressure, which may result in improvement of the cardiopulmonary circulation,…
The objective of this thesis is to get insight into the effects of internal audits on patient safety and on health care professional’s behavior in an academic hospital at ward level.
LHB tenotomy does not lead to inferior functional results as compared to LHB tenodesis when performed in conjunction with an arthroscopic repair of a moderately sized rotator cuff (supraspinatus/infraspinatus tendon) tear in patients 50 years or…
It has been demonstrated that VATS is a good alternative treatment option for chest drainage in children with parapneumonic effusion. Clinical improvement even seems to occur faster after VATS, indicating that when VATS is performed in an early…