6344 resultaten
Thermoregulation in patients with spinal cord injury and cold sensations, an explorative pilot-study
We hypothesize that patients with regular complaints of cold sensations have impaired thermoregulatory responses to changes in environmental temperature. We expect that they are not able to stabilize their core body temperature during changes in…
1. Alcohol marketing influences youth drinking 2. The following factors moderate of mediate the relationship between marketing & drinking: a. Personal relevance of advertisements, b. Sociability, parental guidance in understanding TV and…
End stage kidney disease (ESKD) ranks among the most severe chronic non-communicable diseases with an unmet medical need, given the high (between 10% and 20%) and stable annual mortality rates in ESKD patients treated with dialysis. Kidney…
Donor-specific antibodies form a significant barrier in transplantation of highly pre-sensitized dialysis patients. Increased waiting time is associated with increased morbidity and mortality among these patients. Thus, there is a need to further…
To assess whether temporary discontinuation of antihypertensive therapy in mildly cognitively impaired older patients on antihypertensive treatment improves cognitive and psychological functioning.
The hypothesis is that low dose GC therapy exerts its anti-inflammatory effect by virtue of a first-pass effect through the liver. It is difficult to directly address the hypothesis, but there is an indirect way of doing so: if indeed low dose GCs…
Despite appropriate antimicrobial therapy and supportive care, septic shock is still a major cause of mortality and morbidity. Within the last decade, a broad body of evidence suggests a potential role for mesenchymal stromal cell (MSC, a…
Primary Objective: The primary aim of the current study is to examine whether CFT is effective for reducing self-criticism in patients with PDs or PTSD. We hypothesize that CFT reduces the level of self-criticism. Secondary Objective(s): To examine…
We hypothesize that inhalation of helium gas induces release of protective factors in the blood, which can be used to protect different cell types against ischemia/reperfusion injury.
In the Netherlands over 10.000 patients are diagnosed with head and neck cancer or lung cancer every year of whom 25-50% have comorbid anxiety or depression. Is a stepped care strategy applied in an oncological setting more (cost-)effective to…
The guided online CBT intervention is expected to show favorable effects and to be cost-effective in comparison to care-as-usual for patients with insomnia in general practice
Medication reconciliation using an e-health application is as good as structured medication reconciliation by a pharmacy technician
To investigate the trajectories of cognitive and adaptive functioning in adults with epilepsy and ID. In doing so we are looking for clinical determinants of cognitive and adaptive decline. Furthermore, the association between decline and serum…
We hypothesize that preoperative initiation (7 days before surgery) and perioperative continuation (until day 2 after surgery) of empagliflozin 10 mg daily (10 days total) will reduce the postoperative concentration of NGAL in plasma on…
Primary 1. An immediate invasive approach (immediate angiography and revascularization when appropriate) results in a reduction of the combined incidence of death, re-infarction or recurrent ischemia at 30 days follow-up. Secondary 1. An immediate…
We hypothesize that physical exercise during cancer treatment by reducing complaints of fatigue will lead to a reduction in sick leave and production losses. Altogether we expect that physical exercise during cancer treatment will be cost-effective.
Patients supported by the intervention version of the app will report a significantly higher quality of life than cancer patients having an urostomy who are supported by the control version of the app.
A self-management programme guided by doctors and a specialist asthma nurse through information and communication technology will improve asthma related quality of life in a cost-effective way.
Are hemodynamic values obtained by the non invasive hemodynamic measuring device TL-400 comparable with the values obtained by the standard invasive hemodynamic measuring devices (transpulmonary thermodilution (TPTD) (PiCCO system; Pulsion Medical…