34 results
The primary study objective is to assess the proportion of patients who remain within the IGF-I age adjusted normal limits with pasireotide LAR (60 mg) monotherapy, after 24 weeks of treatment.Secondary study objectives are assessment of the…
1) To perform gene mutation analysis in family members of patients carrying a proven mutation in the candidate gene.2) To determine the clinical, biochemical and radiological characteristics of carriers of a mutation in the candidate gene.3) To…
To assess the impact of treatment with rhGH on circulating Klotho levels in paediatric patients with IGHD.
To determine the incidence of hypopituitarism in patients after SAHTo identify neurological parameters that predict hypopituitarism after SAHTo determine the value of a Ghrelin test shortly after SAH, to identify subjects with GHD.To determine the…
1. Are there differences between patients and controls in circadian movement rhythmicity and sleep duration?2. Are these objective measures associated with subjective sleep complaints?3. Are these objective measures associated with decreased quality…
To understand, from the perspective of the 3-hit hypothesis of psychopathology, individual differences in the neuropsychiatric outcome of previous glucocorticoid (GC) excess in treated Cushing patients.
To assess the presence of GH deficiency in patients who are in long-term remission of Cushing*s syndrome due to adrenal adenoma.
To investigate if there are differences in serotonin transporters in the hypothalamus between subjects with hypopituitarism suspect for hypothalamic damage, subjects with hypopituitarism and no suspicion of hypothalamic damage and healthy age- and…
To describe the differences in macrophage infiltration and mRNA expression of adipocytokines in subcutaneous, omental and perirenal fat tissue in Cushing's syndrome compared to healthy controls.
Objective: Main objective of this study is to compare the area under the MPH saliva concentration versus time curve (AUC) following ingestion of immediate and sustained release formulations of MPH in children with ADHD. Secondary objectives are: 1.…
We aim to investigate thirst in the above mentioned patient groups, applying a Visual Analogue Scale (VAS) and, where ethically acceptable, a new thirst provocation test which we will develop in a group of healthy probands. Using these tools, we aim…
The objective of the current proposal is to further explore the pathophysiological changes that occur in patient with an IGSF1 mutation, using an established method for assessing hormone secretory characteristics.
Our main aim is to describe the 24-h circadian rhythm of skin and core body temperature in people with SCI and examine whether changes in melatonin and/or cortisol relate to the altered circadian rhythm in core body temperature recently described in…
ObjectiveTo assess the prevalence of PHD and chronic fatigue in Dutch TBI patients, and to study the relationships between the various aspects of chronic fatigue and PHD, with particular emphasis on the association between chronic fatigue, and…
Primary objective: To evaluate whether patients with a prolactinoma have signs of altered vascular function and/or morphology in the retina or sublingual tissues in comparison to healthy controls. Secondary Objectives: 1. To evaluate whether there…
Hypothesis:1. Patients who suffer from a hypopituitarism and an adult-onset growth hormone deficiency (AGHD) express more atherosclerotic disease in the coronary system (compared with a historically formed control subjects, present as a database in…
Whether cognitive functions in SGA children are impaired due to inappropriate developmental outgrowth in children born with a low birth weight is unknown. This is also the case for the fact whether GH treatment from the age of 4 years is still…
The following research questions will be addressed: 1.Is there irreversible joint damage after previous GH excess in long-term cured acromegalic patients?2.What are the clinical characteristics of reported joint problems on clinical examination? 3.…
To determine whether hypothalamic response to glucose ingestion in patients with anorexia nervosa differs from that in healthy subjects.
The aim of this study is to classify hyothalamic dysfunction in patients treated for pituitary tumors. The hypothalamic functions will be investigated in different studygroups, these groups each have a different risk on hypothalamic dysfunction.