197 results
To examine the effect of BCG vaccination on the composition and function of the bone marrow.
1. Immunology and Pathology:To determine the immune response of patients with simple and complex appendicitis in order to identify markers which distinguish between simple and complex appendicitis.2.Clinical and Imaging:To analyze the differences in…
Within this project we aim to determine the energetic conditions that underlie the transition to hypertrophy of the HOCM heart. A prospective comparison will be made between results of PET, MRI and function of cardiac myofilaments (in vitro). Also,…
We investigated the safety and efficacy of on-demand SPG stimulation for chronic CH (CCH).
The primary objective is to evaluate the difference in 68Ga-exendin tracer accumulation in the pancreas of patients with and without complete resolution of T2DM after RYGB by quantitative analysis of PET images.
The main objective is to examine if 68Ga-exendin tracer accumulation (i.e. beta cell mass) differs in patients with persisting HH after RYGB compared to matched patients without HH after RYGB. The secondary objectives are:- compare GLP1 and GIP…
We aim to test the effectiveness of a patient-targeted preparatory tool (*Gesprekswijzer*) and an oncologist-targeted communication skills training to enhance shared decision making in consultations about palliative systemic treatment. The primary…
The primary objective is to elucidate whether there is a difference in the outcome of health parameters between IVF children who as an embryo were cultured in two different culture media. As secondary objectives we will investigate how the health…
The primary objective is to determine the safety and tolerability BCG vaccination followed by controlled human malaria infection; and to determine the protective efficacy BCG vaccination against a controlled human malaria infection.
This study aims at (further) revealing the pathophysiology of intestinal IR in man, with a specific interest for the role of proteases and protease-activated receptor-2 (PAR-2), cellular and inflammatory changes, barrier function and intestinal…
The main objective of this study is to assess the ability of a wearable measurement system, the Hexoskin smart shirt, to detect and quantify dynamic hyperinflation. Secondary objectives are to determine the optimal measurement procedure and to…
1. Determine body composition of MD patients;2. Determine physical function of MD patients;3. Determine the association of body composition and physical function of MD patients.
The main objective of this study is to determine the language representation in the brain of children with SLI and 22q11DS.
This project aims to understand the symptomatology PD in the light of functional brain interactions, in the hope of elucidating the role of the frontal striatal system to behaviour.
To compare sex differences in brain functioning using functional magnetic resonance imaging (fMRI) in healthy pre-pubertal boys and girls with a group of children diagnosed with GID. Subjects will have a second fMRI scan, as soon as they enter…
1) To evaluate the feasibility and the acute effect of intra-operative cryoablation of the slow conducting anatomical isthmuses (endpoint bidirectional conduction block) and on the re-inducibility of monomorphic isthmus dependent VT. 2) To study the…
The main objective of this study is to test whether cognitive behaviour therapy delivered by internet has a significant effect on fatigue in patients with type 1 diabetes en whether this effect is sustained during a follow-up period of six months.…
The aim of this MRI study is to understand how neurodegeneration in MS (in vivo) is related to other facets of MS pathology, i.e. inflammatory (T2) lesions, black hole (T1) lesions, cortical lesions and damage of the normal appearing brain tissue.…
The overall aim of the present work is to evaluate the individual role of androgens and estrogens on brain function in the human with a focus on cognition. Both clinical models give us the opportunity to evaluate cognitive functions and brain…
The objective is to investigate the effects of a combined strength and aerobic exercise program on cognition, physical functioning, social functioning and ADL.