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A randomised phase III trial comparing a strategy based on molecular analysis to the empiric strategy in patients with carcinoma of an unknown primary;A la carte CUP treatment using the CancerTYPE ID test

Determine wether or not a strategy based on molecular analysis is effective in improving the PFS

Effect of Spinal Cord Stimulation in Painful Diabetic Polyneuropathy: a multicenter Randomised Controlled Trial (PDP study)

The primary objective of this study is to investigate whether SCS combined with best (drug) treatment as usual (TAU) leads to clinically significant (>=50%) pain relief in patients suffering from moderate-to-severe PDP in the lower limbs…

A phase 1, placebo-controlled, ascending-dose study to assess the safety and imaging characteristics of GE-137 Injection in healthy volunteers, and to assess its safety and imaging characteristics in subjects with high suspicion of colorectal cancer

The study the safety and imaging characteristics of GE-137

Toward a More Effective Treatment of Obesity: A RCT on Emotional Eating Reduction by Dialectical Behaviour Therapy

This study assesses the effectiveness of DBT in comparison to the effectiveness of the treatment as usual, the (standard) cognitive behavioural therapy, by using a randomised controlled design situated in the eating disorder and obesity unit of…

Displaced midshaft fractures of the clavicle: non-operative treatment versus Acumed ® plate fixation. A multi-centre randomised controlled trial in the Netherlands.

Results of recent trials suggest that operative treatment with locking plate fixation results in better functional outcomes than non-operative treatment. Because more patients were lost to follow-up than anticipated in the main randomised trial,…

European Health Economic Trial on home monitoring in ICD and CRT-D patients

This amendment (extension to CRT-D subjects) aims to assess the economic effects of HM technology vs. classical follow-up of CRT-D patients from two perspectives: 1) the cost-effectiveness for the payer of health care, and 2) the economic impact on…

Optimal Timing of Coronary Intervention in Unstable Angina 2

The objective for this trial is to evaluate an invasive strategy using urgent PCI (<3h) as compared to an early PCI (24h) using novel quick acting antiplatelet therapy.

The effectiveness of Mindfulness Based Compassionate Living (MBCL) in adults with recurrent depression.

To investigate the effectiveness of Mindfulness Based Compassionate Living (MBCL) in recurrent depressive patients.

Bilateral Cochlear Implantation Benefits in Adult Users of the HiRes 90K Bionic Ear System

1) Compare a group of bilateral users to a unilateral control group (between-subject design)2) Compare unilateral use to bilateral use after sequential implantation (within-subject design)3) Compare simultaneous bilateral implantation to sequential…

Bladder training with or without PTNS(Posterior Tibial Nerve Stimulation) in the treatment of Overactive Bladder

The main objective of this study will be to assess whether an additive stimulation of the posterior tibial nerve (PTNS) in combination with bladder training has a significant reduction in frequency of micturition in patients with overactive bladder…

A prospective, randomised multicenter controlled trial on the treatment of intra-articular distal radius fractures; open reduction and internal fixation with volair angle stable plating versus percutaneous reduction and fixation in combination with an external fixator

The goal of this study will be to determine a functional benefit and an increase in patient satisfaction after a period of one year of open reduction and internal fixation (ORIF) by volar approach versus percutaneous reposition and fixation with…

Switch from a NNRTI or PI-based regimen to a RAltegravir-based regimen in virologically suppressed HIV-infected patients: effects on Platelet reactivity, platelet-monocyte aggregation and the Inflammatory anD thrombotic state of monocytes

Investigate whether switch from a non-nucleoside reverse transcriptase inhibitor (NNRTI)- or protease inhibitor (PI)-based regimen to a raltegravir-based regimen results in reduced platelet reactivity, reduced platelet-leukocyte aggregate formation…

Intrathoracic versus Cervical ANastomosis after minimally invasive esophagectomy for esophageal cancer: a randomized controlled trial

The ICAN research question is: What is the effectiveness of an intrathoracic compared to a cervical esophagogastric anastomosis after (hybrid) minimally invasive esophagectomy in terms of anastomotic leakage, morbidity, quality of life and costs?

Acute anterior cruciate ligament rupture: RecOnsTruction Or Repair?

Primary goal: Investigate the hypothesis that suture repair of a ruptured vkb, combined with a dynamic intraligamentary stabilization and microfracture of the femoral notch, results in at least equal effectiveness compared with an ACL reconstruction…

The use of Prevena Incision Management System on clean closed sternal midline incisions in subjects at high risk for surgical site occurrences.

The objective of the study is to assess the performance of topical negative pressure therapy application with Prevena* Incision Management System (IMS) versus standard conventional wound therapy (SCWT) on closed median sternal incisions in patients…

A multicenter, randomized, open-label, blinded-assessor, phase 4 study in patients with early rheumatoid arthritis to compare active conventional therapy versus three biologic treatments, and two de-escalation strategies in patients who respond to treatment.

The objective of the study is to compare conventional therapy with biological therapy in patients with early rheumatoid arthritis.

The safety and efficacy of implementing the PreHEART decision support tool by the Emergency Medical Service for patients with undifferentiated chest pain: a prospective randomized open blinded end-point study (PreHeart-3 study)

Primary Objective: 1. To determine the non-inferiority of pre-hospital risk stratification and care path selection through the preHEART algorithm as compared to usual care with respect to the occurrence of unexpected serious adverse events (USAE) in…

The influence of young child formula containing short-chain galactooligosaccharides, long-chain fructooligosaccharides and n-3 long-chain polyunsaturated fatty acids on recurrent upper respiratory tract infections in children: a randomised, controlled trial.

To evaluate whether YCF with added scGOS/lcFOS and n-3 LCPFUAs can decrease the number of upper respiratory tract infections compared to cow*s milk in children aged 12-36 months with recurrent upper respiratory tract infections.

Primary care decision rule for chest pain using the Marburg heart score rule and troponin point of care test

To determine the effectiveness of a decision rule compared to the usual care of GP*s for patients presenting with non-traumatic chest pain in primary care.

Hypnotherapy through self-exercises in children with functional abdominal pain
in primary care

To determine the (cost)-effectiveness of home-based hypnotherapy by self-exercises added to usual care (UC) of general practitioners (GPs) compared with UC of GPs alone in children with FAP or IBS.